Anticancer, antimicrobial, and analgesic activities of spider venoms

被引：30
作者：
Akef, Hassan M. [1 ]
机构：
[1] Natl Org Res & Control Biol NORCB, Giza, Egypt
来源：
TOXICOLOGY RESEARCH | 2018年 / 7卷 / 03期
关键词：
ION-CHANNEL; 1A; ACTIVATED CALCIUM-CHANNELS; PEPTIDE LYCOSIN-I; PHONEUTRIA-NIGRIVENTER; ACANTHOSCURRIA-GOMESIANA; P2X(3) RECEPTORS; SODIUM-CHANNELS; CANCER-CELLS; ORNITHOCTONUS-HUWENA; SELENOCOSMIA-HUWENA;
D O I：
10.1039/c8tx00022k
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Spider venoms are complex mixtures composed of a variety of compounds, including salts, small organic molecules, peptides, and proteins. But, the venom of a few species is dangerous to humans. High levels of chemical diversity make spider venoms attractive subjects for chemical prospecting. Many spider venom components show potential activity against a wide range of human diseases. However, the development of novel venom-derived therapeutics requires an understanding of their mechanisms of action. This review will highlight the structures, activities and the possible mechanisms of action of spider venoms and their components against cancer, microbial infections, and pain.
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收藏
页码：381 / 395
页数：15
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