Targeting Breast Cancer Stem Cells: A Methodological Perspective

被引：4

作者：

Velasco-Velazquez, Marco A. ^{[1
,2
]}

Velazquez-Qucsada, Nos ^{[1
,3
]}

Vasquez-Bochm, Luz X. ^{[1
,4
]}

Perez-Tapia, Sonia M. ^{[3
]}

机构：

[1] Univ Nacl Autonoma Mexico, Fac Med, Dept Farmacol, Circuito Interne S-N, Ciudad De Mexico 04510, Mexico

[2] UNAM, Fac Med, Unidad Perifer Invest Biomed Traslac, Ciudad De Mexico, Mexico

[3] Inst Politecn Nacl, ENCB, Unidad Desarrollo & Invest Bioproc, Ciudad De Mexico, Mexico

[4] UNAM, Posgrad Ciencias Quim, Ciudad De Mexico, Mexico

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2019年 / 14卷 / 05期

关键词：

Cancer stem cells; anticancer drugs; self-renewal; CSC selective toxicity; CSC differentiation; breast tumors; IN-VITRO PROPAGATION; SELF-RENEWAL; ALDEHYDE DEHYDROGENASE; MAMMOSPHERE CELLS; INITIATING CELLS; REPORTER SYSTEM; CLAUDIN-LOW; MODELS; IDENTIFICATION; METASTASIS;

D O I：

10.2174/1574888X13666180821155701

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Cancer Stern Cells (CSCs) constitute a subpopulation at the top of the tumor cell hierarchy that contributes to tumor heterogeneity and is uniquely capable of seeding new tumors. Because of their biological properties, CSCs have been pointed out as therapeutic targets for the development of new therapies against breast cancer. The identification of drugs that selectively target breast CSCs requires a clear understanding of their biological functions and the experimental methods to evaluate such hallmarks. Herein, we review the methods to study breast CSCs properties and discuss their value in the preclinical evaluation of CSC-targeting drugs.

引用

页码：389 / 397

页数：9

共 113 条

[1] A CD44-/CD24+ phenotype is a poor prognostic marker in early invasive breast cancer [J].

Ahmed, Mohamed A. H. ;

Aleskandarany, Mohammed A. ;

Rakha, Emad A. ;

Moustafa, Radwa Z. A. ;

Benhasouna, Ahmed ;

Nolan, Christopher ;

Green, Andrew R. ;

Ilyas, Mohammad ;

Ellis, Ian O. .

BREAST CANCER RESEARCH AND TREATMENT, 2012, 133 (03) :979-995

[2] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[3] Self-renewal and solid tumor stem cells [J].

Al-Hajj, M ;

Clarke, MF .

ONCOGENE, 2004, 23 (43) :7274-7282

[4] Exploring the role of cancer stem cells in radioresistance [J].

Baumann, Michael ;

Krause, Mechthild ;

Hill, Richard .

NATURE REVIEWS CANCER, 2008, 8 (07) :545-554

[5] Selection of Tumorigenic Melanoma Cells Using ALDH [J].

Boonyaratanakornkit, Jim B. ;

Yue, Lili ;

Strachan, Lauren R. ;

Scalapino, Kenneth J. ;

LeBoit, Philip E. ;

Lu, Ying ;

Leong, Stanley P. ;

Smith, Janellen E. ;

Ghadially, Ruby .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 (12) :2799-2808

[6] Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy [J].

Borah, A. ;

Raveendran, S. ;

Rochani, A. ;

Maekawa, T. ;

Kumar, D. S. .

ONCOGENESIS, 2015, 4 :e177-e177

[7] To differentiate or not - routes towards metastasis [J].

Brabletz, Thomas .

NATURE REVIEWS CANCER, 2012, 12 (06) :425-436

[8] Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells [J].

Chadwick, K ;

Wang, LS ;

Li, L ;

Menendez, P ;

Murdoch, B ;

Rouleau, A ;

Bhatia, M .

BLOOD, 2003, 102 (03) :906-915

[9] Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature [J].

Charafe-Jauffret, Emmanuelle ;

Ginestier, Christophe ;

Iovino, Flora ;

Wicinski, Julien ;

Cervera, Nathalie ;

Finetti, Pascal ;

Hur, Min-Hee ;

Diebel, Mark E. ;

Monville, Florence ;

Dutcher, Julie ;

Brown, Marty ;

Viens, Patrice ;

Xerri, Luc ;

Bertucci, Francois ;

Stassi, Giorgio ;

Dontu, Gabriela ;

Birnbaum, Daniel ;

Wicha, Max S. .

CANCER RESEARCH, 2009, 69 (04) :1302-1313

[10] Understanding and targeting cancer stem cells: therapeutic implications and challenges [J].

Chen, Ke ;

Huang, Ying-hui ;

Chen, Ji-long .

ACTA PHARMACOLOGICA SINICA, 2013, 34 (06) :732-740

← 1 2 3 4 5 6 7 8 9 10 →