Role of OmpA in the Multidrug Resistance Phenotype of Acinetobacter baumannii

被引：137
|
作者：
Smani, Younes [1 ]
Fabrega, Anna [2 ]
Roca, Ignasi [2 ]
Sanchez-Encinales, Viviana [1 ]
Vila, Jordi [2 ]
Pachon, Jeronimo [1 ]
机构：
[1] Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS,Clin Unit Infect Dis Mic, Seville, Spain
[2] Univ Barcelona, Hosp Clin, CRESIB, Dept Clin Microbiol,Sch Med,Barcelona Ctr Int Hlt, Barcelona, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 03期
关键词：
EFFLUX PUMP; PSEUDOMONAS-AERUGINOSA; EXPRESSION; PORIN; CELLS; COLI;
D O I：
10.1128/AAC.02101-13
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Acinetobacter baumannii has emerged as a nosocomial pathogen with an increased prevalence of multidrug-resistant strains. The role of the outer membrane protein A (OmpA) in antimicrobial resistance remains poorly understood. In this report, disruption of the ompA gene led to decreased MICs of chloramphenicol, aztreonam, and nalidixic acid. We have characterized, for the first time, the contribution of OmpA in the antimicrobial resistance phenotype of A. baumannii.
引用
收藏
页码：1806 / 1808
页数：3
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