Fatal liaisons of p53 with Bax and Bak

被引：69

作者：

Perfettini, JL

Kroemer, RT

Kroemer, G

机构：

[1] Inst Gustave Roussy, CNRS, UMR8125, Apoptosis Canc & Immun Lab, F-94805 Villejuif, France

[2] Mol Modeling & Design Pharm, I-20014 Nerviano, MI, Italy

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 05期

关键词：

D O I：

10.1038/ncb0504-386

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

p53 can induce apoptosis through its well defined role as a regulator of transcription, but also by a less well defined transcription-independent mechanism. Two recent studies demonstrate that p53 mediates mitochondrial permeabilization through direct physical interactions with the pro-apoptotic Bcl-2 family members, Bax and Bak.

引用

页码：386 / 388

页数：3

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