New crystalline N-(coumarin-4-yl)-L-pyroglutamic acid. The first synthesis and application to H-1 NMR optical purity determination of alcohols and amines

被引：5

作者：

Nagasawa, K

Okazaki, R

Yamashita, A

Ito, K

Wada, K

机构：

[1] Hokkaido College of Pharmacy, Otaru 047-02

来源：

HETEROCYCLES | 1997年 / 45卷 / 06期

关键词：

D O I：

10.3987/COM-97-7775

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Condensation of 3-phenylsulfonyl-4-chlorocoumarin with tert-butyl L-pyroglutamate potassium salt followed by desulfonylation and ester-cleavage yielded the novel crystalline N-(coumarin-4-yl)-L-pyro-glutamic acid[CPYR0-0H], which being evidenced to be a versatile and reliable H-1 nmr optical purity determination agent for chiral alcohols and amines.

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收藏

页码：1047 / 1050

页数：4

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