Critical Review on the Analytical Methods for the Estimation of Clofazimine in Bulk, Biological Fluids and Pharmaceutical Formulations

被引：13
|
作者：
Patil, Tulshidas S. [1 ]
Deshpande, Ashwini S. [1 ]
Deshpande, Shirish [1 ]
机构：
[1] SVKMs NMIMS, Sch Pharm & Technol Management, Shirpur, Maharashtra, India
来源：
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY | 2018年 / 48卷 / 06期
关键词：
Clofazimine; analytical methods; biological fluids; dosage forms; PERFORMANCE LIQUID-CHROMATOGRAPHY; MULTIDRUG-RESISTANT TUBERCULOSIS; MYCOBACTERIUM-AVIUM COMPLEX; THIN-LAYER-CHROMATOGRAPHY; LEPROSY PATIENTS; THERAPEUTIC-EFFICACY; IN-VITRO; INFECTION; PLASMA; SERUM;
D O I：
10.1080/10408347.2018.1451298
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Clofazimine (CFZ), a riminophenazine derivative and a crucial drug in the treatment of lepromatous leprosy, has been reintroduced clinically to treat multidrug-resistant tuberculosis. CFZ holds both antimycobacterial and anti-inflammatory properties. But, due to its highly hydrophobic, polar and photosensitive nature, it is challenging to extract and quantify the drug from different biological fluids and its pharmaceutical formulations. This has also hampered the pharmacokinetic evaluation of the CFZ.This article accentuates various analytical methods viz. Identification methods, titrimetric methods, spectrometric methods such as colorimetric, fluorometric, mass spectroscopy and UV/Vis spectroscopy, Chromatographic methods like paper chromatography, thin-layer chromatography, high-performance thin layer chromatography, high-performance liquid chromatography, liquid chromatography tandem mass spectrometry for the estimation of CFZ in bulk, biological fluids and its pharmaceutical formulations.
引用
收藏
页码：492 / 502
页数：11
相关论文
共 50 条
  • [1] Analytical methods for favipiravir: A critical review of estimation in bulk, biological fluids, and formulations
    Mahajan, Mahendra R.
    Kushwaha, Omkar S.
    Gopinath, Subash C. B.
    More, Mahesh P.
    Patil, Narendra B.
    Bari, Sanjaykumar B.
    Patil, Pravin O.
    MICROCHEMICAL JOURNAL, 2025, 212
  • [2] Analytical Methods for the Determination of Rosuvastatin in Pharmaceutical Formulations and Biological Fluids: A Critical Review
    Angelo, Marilene Lopes
    Moreira, Fernanda de Lima
    Morais Ruela, Andre Luis
    Araujo Santos, Ana Laura
    Nunes Salgado, Herida Regina
    de Araujo, Magali Benjamim
    CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, 2018, 48 (04) : 317 - 329
  • [3] Critical Review on the Analytical Techniques for the Determination of the Oldest Statin-Atorvastatin-in Bulk, Pharmaceutical Formulations and Biological Fluids
    Kokilambigai, K. S.
    Seetharaman, R.
    Lakshmi, K. S.
    CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, 2017, 47 (06) : 538 - 555
  • [4] A Critical Review of Analytical Methods for Quantification of Amphotericin B in Biological Samples and Pharmaceutical Formulations
    Marena, Gabriel Davi
    Ramos, Matheus Aparecido dos Santos
    Bauab, Tais Maria
    Chorilli, Marlus
    CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, 2022, 52 (03) : 555 - 576
  • [5] Analytical Methods for Determination of Apremilast from Bulk, Dosage Form and Biological Fluids: A Critical Review
    Kulkarni, Pooja
    Deshpande, Ashwini
    CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, 2021, 51 (03) : 258 - 267
  • [6] An Overview of Analytical Methods for the Determination of Monoamine Oxidase Inhibitors in Pharmaceutical Formulations and Biological Fluids
    Saka, Cafer
    CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, 2017, 47 (01) : 1 - 23
  • [7] Lamotrigine-A Review of Analytical Methods Developed for Pharmaceutical Formulations and Biological Matrices
    Sajeeda, S.
    Kumar, Lalit
    Verma, Ruchi
    CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, 2022, 52 (07) : 1451 - 1460
  • [8] Remdesivir: A Review on Analytical Methods for Drug Substances, Pharmaceutical Formulations, and Biological Matrices
    de Almeida Bertassoni, Breno
    Pinto, Eduardo Costa
    de Amorim, Magali Silva
    de Moraes, Marcela Cristina
    CURRENT PHARMACEUTICAL ANALYSIS, 2024,
  • [9] Ezetimibe: A Review of Analytical Methods for the Drug Substance, Pharmaceutical Formulations and Biological Matrices
    Rocha, Leticia Pereira
    Cabral, Lucio Mendes
    Pinto, Eduardo Costa
    de Sousa, Valeria Pereira
    CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, 2022, 52 (05) : 1078 - 1093
  • [10] An Overview of Analytical Methods for the Estimation of Propofol in Pharmaceutical Formulations, Biological Matrices, and Hair Marker
    Sajeeda, S.
    Kumar, Lalit
    Verma, Ruchi
    CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, 2022, 52 (07) : 1694 - 1701
12345