Membrane Protein Biogenesis: PAT Complex Pats Membrane Proteins into Shape

被引：2

作者：

Culver, Jacob A. ^{[1
]}

Mariappan, Malaiyalam ^{[1
]}

机构：

[1] Yale Sch Med, Nanobiol Inst, Dept Cell Biol, 850 West Campus, West Haven, CT 06516 USA

来源：

CURRENT BIOLOGY | 2020年 / 30卷 / 22期

关键词：

ASSOCIATION; INTEGRATION; TRANSLOCON; VARIANTS; GLAUCOMA; TMCO1;

D O I：

10.1016/j.cub.2020.09.072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Membrane proteins with multiple transmembrane domains play essential roles in the cell, but little is known about the machinery involved in the assembly of these domains into functional proteins. Two recent studies report the discovery of novel membrane protein chaperone complexes for the biogenesis of multi-pass membrane proteins.

引用

页码：R1387 / R1389

页数：3

共 18 条

[1] Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum [J].

Anghel, S. Andrei ;

McGilvray, Philip T. ;

Hegde, Ramanujan S. ;

Keenan, Robert J. .

CELL REPORTS, 2017, 21 (13) :3708-3716

[2] In vivo aspects of protein folding and quality control [J].

Balchin, David ;

Hayer-Hartl, Manajit ;

Hartl, F. Ulrich .

SCIENCE, 2016, 353 (6294)

[3] Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1 [J].

Burdon, Kathryn P. ;

Macgregor, Stuart ;

Hewitt, Alex W. ;

Sharma, Shiwani ;

Chidlow, Glyn ;

Mills, Richard A. ;

Danoy, Patrick ;

Casson, Robert ;

Viswanathan, Ananth C. ;

Liu, Jimmy Z. ;

Landers, John ;

Henders, Anjali K. ;

Wood, John ;

Souzeau, Emmanuelle ;

Crawford, April ;

Leo, Paul ;

Wang, Jie Jin ;

Rochtchina, Elena ;

Nyholt, Dale R. ;

Martin, Nicholas G. ;

Montgomery, Grant W. ;

Mitchell, Paul ;

Brown, Matthew A. ;

Mackey, David A. ;

Craig, Jamie E. .

NATURE GENETICS, 2011, 43 (06) :574-U110

[4] An intramembrane chaperone complex facilitates membrane protein biogenesis [J].

Chitwood, Patrick J. ;

Hegde, Ramanujan S. .

NATURE, 2020, 584 (7822) :630-+

[5] EMC Is Required to Initiate Accurate Membrane Protein Topogenesis [J].

Chitwood, Patrick J. ;

Juszkiewicz, Szymon ;

Guna, Alina ;

Shao, Sichen ;

Hegde, Ramanujan S. .

CELL, 2018, 175 (06) :1507-+

[6] Cotranslational Stabilization of Sec62/63 within the ER Sec61 Translocon Is Controlled by Distinct Substrate-Driven Translocation Events [J].

Conti, Brian J. ;

Devaraneni, Prasanna K. ;

Yang, Zhongying ;

David, Larry L. ;

Skach, William R. .

MOLECULAR CELL, 2015, 58 (02) :269-283

[7] Designing minimalist membrane proteins [J].

Curnow, Paul .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2019, 47 :1233-1245

[8] The translocon: A dynamic gateway at the ER membrane [J].

Johnson, AE ;

van Waes, MA .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1999, 15 :799-842

[9] An ER translocon for multi-pass membrane protein biogenesis [J].

McGilvray, Philip T. ;

Anghel, S. Andrei ;

Sundaram, Arunkumar ;

Zhong, Frank ;

Trnka, Michael J. ;

Fuller, James R. ;

Hu, Hong ;

Burlingame, Alma L. ;

Keenan, Robert J. .

ELIFE, 2020, 9

[10] Different transmembrane domains associate with distinct endoplasmic reticulum components during membrane integration of a polytopic protein [J].

Meacock, SL ;

Lecomte, FJL ;

Crawshaw, SG ;

High, S .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (12) :4114-4129

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