Predictors of Autosomal Dominant Polycystic Kidney Disease Progression

被引:127
作者
Schrier, Robert W. [1 ]
Brosnahan, Godela [1 ]
Cadnapaphornchai, Melissa A. [1 ]
Chonchol, Michel [1 ]
Friend, Keith [2 ]
Gitomer, Berenice [1 ]
Rossettit, Sandro [2 ]
机构
[1] Univ Colorado, Sch Med, Div Renal Dis & Hypertens, Aurora, CO 80045 USA
[2] Otsuka Amer Pharmaceut Inc, Med Affairs, Cardiorenal Dept, Princeton, NJ USA
来源
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2014年 / 25卷 / 11期
关键词
LEFT-VENTRICULAR MASS; MAGNETIC-RESONANCE MEASUREMENTS; AMBULATORY BLOOD-PRESSURE; SERUM URIC-ACID; RENAL-FUNCTION; ENDOTHELIAL DYSFUNCTION; HYPERTENSIVE PATIENTS; NORMOTENSIVE PATIENTS; DIASTOLIC FUNCTION; MISSENSE MUTATION;
D O I
10.1681/ASN.2013111184
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Autosomal dominant polycystic kidney disease is a genetic disorder associated with substantial variability in its natural course within and between affected families. Understanding predictors for rapid progression of this disease has become increasingly important with the emergence of potential new treatments. This systematic review of the literature since 1988 evaluates factors that may predict and/or effect autosomal dominant polycystic kidney disease progression. Predicting factors associated with early adverse structural and/or functional outcomes are considered. These factors include PKD1 mutation (particularly truncating mutation), men, early onset of hypertension, early and frequent gross hematuria, and among women, three or more pregnancies. Increases in total kidney volume and decreases in GFR and renal blood flow greater than expected for a given age also signify rapid disease progression. Concerning laboratory markers include overt proteinuria, macroalbuminuria, and perhaps, elevated serum copeptin levels in affected adults. These factors and others may help to identify patients with autosomal dominant polycystic kidney disease who are most likely to benefit from early intervention with novel treatments.
引用
收藏
页码:2399 / 2418
页数:20
相关论文
共 109 条
  • [1] Ahmed ER, 2006, SAUDI J KIDNEY DIS T, V17, P511
  • [2] Augustyniak-Bartosik H, 2008, ADV CLIN EXP MED, V17, P155
  • [3] Vasopressin: a novel target for the prevention and retardation of kidney disease?
    Bankir, Lise
    Bouby, Nadine
    Ritz, Eberhard
    [J]. NATURE REVIEWS NEPHROLOGY, 2013, 9 (04) : 223 - 239
  • [4] Left ventricular mass and diastolic function in normotensive young adults with autosomal dominant polycystic kidney disease
    Bardají, A
    Vea, AM
    Gutierrez, C
    Ridao, C
    Richart, C
    Oliver, JA
    [J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 1998, 32 (06) : 970 - 975
  • [5] Family History of Renal Disease Severity Predicts the Mutated Gene in ADPKD
    Barua, Moumita
    Cil, Onur
    Paterson, Andrew D.
    Wang, Kairon
    He, Ning
    Dicks, Elizabeth
    Parfrey, Patrick
    Pei, York
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (08): : 1833 - 1838
  • [6] The effect of caffeine on renal epithelial cells from patients with autosomal dominant polycystic kidney disease
    Belibi, FA
    Wallace, DP
    Yamaguchi, T
    Christensen, M
    Reif, G
    Grantham, JJ
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2002, 13 (11): : 2723 - 2729
  • [7] Familial clustering of ruptured intracranial aneurysms in autosomal dominant polycystic kidney disease
    Belz, MM
    Hughes, RL
    Kaehny, WD
    Johnson, AM
    Fick-Brosnahan, GM
    Earnest, MP
    Gabow, PA
    [J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 2001, 38 (04) : 770 - 776
  • [8] Relationship of Copeptin, a Surrogate Marker for Arginine Vasopressin, With Change in Total Kidney Volume and GFR Decline in Autosomal Dominant Polycystic Kidney Disease: Results From the CRISP Cohort
    Boertien, Wendy E.
    Meijer, Esther
    Li, Jie
    Bost, James E.
    Struck, Joachim
    Flessner, Michael F.
    Gansevoort, Ron T.
    Torres, Vicente E.
    [J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 2013, 61 (03) : 420 - 429
  • [9] Increased left ventricular mass in children with autosomal dominant polycystic kidney disease and borderline hypertension
    Cadnapaphornchai, Melissa A.
    McFann, Kim
    Strain, John D.
    Masoumi, Amirali
    Schrier, Robert W.
    [J]. KIDNEY INTERNATIONAL, 2008, 74 (09) : 1192 - 1196
  • [10] Chapman AB, 1997, J AM SOC NEPHROL, V8, P1292