Relationship between cotinine and trans-3′-hydroxycotinine glucuronidation and the nicotine metabolite ratio in Caucasian smokers

被引：5
作者：
Jacobson, Glenn A. [1 ]
Ferguson, Stuart G. [1 ]
机构：
[1] Univ Tasmania, Sch Med, Hobart, Tas 7001, Australia
来源：
BIOMARKERS | 2014年 / 19卷 / 08期
基金：
英国医学研究理事会;
关键词：
Genotype; nicotine metabolite ratio; smoking cessation; DISPOSITION KINETICS; TRANSDERMAL NICOTINE; SMOKING-CESSATION; CYP2A6; GENOTYPE; UGT2B17; ASSOCIATION; PREDICTS; CANCER; RISK;
D O I：
10.3109/1354750X.2014.966254
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Context: Nicotine metabolite ratio (NMR) is linked with smoking behaviour and quitting, but little is known about the importance of UDP-glucuronosyltransferase metabolism phenotype on NMR. Objective: To investigate the relationship between NMR and UDP-glucuronosyltransferase phenotype in a Caucasian population. Methods: Urine samples from 260 smokers were measured by UPLC-MS/MS for cotinine (COT), 3'-hydroxycotinine, COT-glucuronide and 3'-hydroxycotinine-glucuronide. UDP-glucuronosyltransferase phenotype was assessed using the proportion of metabolites present as the glucuronide. Results: A correlation was found between NMR and UDP-glucuronosyltransferase phenotype for COT (males and females) and 3'-HC in females (p<0.0001). Conclusion: NMR is clearly influenced by UDP-glucuronosyltransferase phenotype for COT in Caucasians.
引用
收藏
页码：679 / 683
页数：5
相关论文
共 24 条
  • [1] The effect of copy number variation in the phase II detoxification genes UGT2B17 and UGT2B28 on colorectal cancer risk
    Angstadt, Andrea Y.
    Berg, Arthur
    Zhu, Junjia
    Miller, Paige
    Hartman, Terryl J.
    Lesko, Samuel M.
    Muscat, Joshua E.
    Lazarus, Philip
    Gallagher, Carla J.
    [J]. CANCER, 2013, 119 (13) : 2477 - 2485
  • [2] COTININE DISPOSITION AND EFFECTS
    BENOWITZ, NL
    KUYT, F
    JACOB, P
    JONES, RT
    OSMAN, AL
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1983, 34 (05) : 604 - 611
  • [3] Pharmacology of nicotine: Addiction and therapeutics
    Benowitz, NL
    [J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1996, 36 : 597 - 613
  • [4] Trans-3′-hydroxycotinine:: Disposition kinetics, effects and plasma levels during cigarette smoking
    Benowitz, NL
    Jacob, P
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2001, 51 (01) : 53 - 59
  • [5] UGT2B10 Genotype Influences Nicotine Glucuronidation, Oxidation, and Consumption
    Berg, Jeannette Zinggeler
    von Weymarn, Linda B.
    Thompson, Elizabeth A.
    Wickham, Katherine M.
    Weisensel, Natalie A.
    Hatsukami, Dorothy K.
    Murphy, Sharon E.
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2010, 19 (06) : 1423 - 1431
  • [6] Glucuronidation Genotypes and Nicotine Metabolic Phenotypes: Importance of Functional UGT2B10 and UGT2B17 Polymorphisms
    Chen, Gang
    Giambrone, Nino E., Jr.
    Dluzen, Douglas F.
    Muscat, Joshua E.
    Berg, Arthur
    Gallagher, Carla J.
    Lazarus, Philip
    [J]. CANCER RESEARCH, 2010, 70 (19) : 7543 - 7552
  • [7] Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity
    Dempsey, D
    Tutka, P
    Jacob, P
    Allen, F
    Schoedel, K
    Tyndale, RF
    Benowitz, NL
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2004, 76 (01) : 64 - 72
  • [8] Nicotine Metabolism in Three Ethnic/Racial Groups with Different Risks of Lung Cancer
    Derby, Kiersten S.
    Cuthrell, Kristine
    Caberto, Christian
    Carmella, Steven G.
    Franke, Adrian A.
    Hecht, Stephen S.
    Murphy, Sharon E.
    Le Marchandl, Loiec
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2008, 17 (12) : 3526 - 3535
  • [9] Exploring the Viability of Using Online Social Media Advertising as a Recruitment Method for Smoking Cessation Clinical Trials
    Frandsen, Mai
    Walters, Julia
    Ferguson, Stuart G.
    [J]. NICOTINE & TOBACCO RESEARCH, 2014, 16 (02) : 247 - 251
  • [10] The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: Sex-specific association with urinary 4-(methyinitrosamino)-1-(3-pyridyl)-1-butanol glucuroniclation phenotype and risk for lung cancer
    Gallagher, Carla J.
    Muscat, Joshua E.
    Hicks, Amy N.
    Zheng, Yan
    Dyer, Anne-Marie
    Chase, Gary A.
    Richie, John
    Lazarus, Philip
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2007, 16 (04) : 823 - 828
123