Exserolides A-F, new isocoumarin derivatives from the plant endophytic fungus Exserohilum sp.

被引：35

作者：

Li, Ruxin ^{[1
,2
]}

Chen, Shenxi ^{[2
]}

Niu, Shubin ^{[2
]}

Guo, Liangdong ^{[3
]}

Yin, Jun ^{[1
]}

Che, Yongsheng ^{[2
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Dev & Utilizat Key Lab Northeast Plant Mat, Shenyang 110016, Peoples R China

[2] Beijing Inst Pharmacol & Toxicol, State Key Lab Antitox Drugs & Toxicol, Beijing 100850, Peoples R China

[3] Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China

来源：

FITOTERAPIA | 2014年 / 96卷

基金：

北京市自然科学基金;

关键词：

Endophytic fungus; Exserohilum sp; Isocoumarins; Antifungal activity; Antibacterial activity; ABSOLUTE-CONFIGURATION; NATURAL-PRODUCTS; METABOLITES; ROSTRATUM; LACTONES; NMR;

D O I：

10.1016/j.fitote.2014.04.013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new isocoumarin derivatives, exserolides A-F (1-6), were isolated from solid cultures of the plant endophytic fungus Exserohilum sp., together with four known metabolites (7-10). The structures of 1-6 were elucidated primarily by NMR experiments. The absolute configuration of the C-3 methine carbon in 1-5 was deduced via the circular dichroism data, whereas that of the 1,3-diol moiety in 6 was assigned from the H-1 NMR data of its (R)- and (S)-MTPA diesters. Compounds 3 and 9 showed antifungal activity against the plant pathogen Fusarium oxysporum, whereas 6 displayed significant inhibitory effects against a small panel of bacteria. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：88 / 94

页数：7

共 27 条

[1] METABOLITES OF HELMINTHOSPORIUM-MONOCERAS - STRUCTURES OF MONOCERIN AND RELATED BENZOPYRANS [J].