A Homologous Bacterin Protects Sheep against Abortion Induced by a Hypervirulent Campylobacter jejuni Clone

被引：3
|
作者：
Wu, Zuowei [1 ]
Yaeger, Michael J. [2 ]
Sahin, Orhan [3 ]
Xu, Changyun [1 ]
Beyi, Ashenafi F. [1 ]
Plummer, Paul J. [1 ,3 ,4 ]
Meral Ocal, Melda [1 ,5 ]
Zhang, Qijing [1 ]
机构：
[1] Iowa State Univ, Vet Microbiol & Prevent Med, Ames, IA 50010 USA
[2] Iowa State Univ, Vet Pathol, Ames, IA 50010 USA
[3] Iowa State Univ, Vet Diagnost & Prod Anim Med, Ames, IA 50010 USA
[4] Natl Inst Antimicrobial Resistance Res & Educ, Ames, IA 50010 USA
[5] Cukurova Univ, Dept Med Microbiol, Fac Med, TR-01330 Adana, Turkey
来源：
VACCINES | 2020年 / 8卷 / 04期
基金：
美国食品与农业研究所;
关键词：
sheep abortion; Campylobacter jejuni; clone SA; bacterin; immunoprotection; OVINE VIBRIOSIS; IMMUNIZATION; VACCINATION; DISEASES;
D O I：
10.3390/vaccines8040662
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Campylobacter jejuni clone SA has emerged as the predominant cause of ovine abortion outbreaks in the United States (US). Despite the fact that commercial Campylobacter vaccines are available, their efficacy in protecting abortion induced by C. jejuni clone SA is uncertain, and a protective vaccine is needed to control the disease. In this study, an experimental homologous bacterin (made of a clone SA isolate) and two commercial Campylobacter vaccines were evaluated for their protection against C. jejuni clone SA-induced sheep abortion. All vaccines induced high levels of antibodies against C. jejuni clone SA in pregnant ewes, but only the experimental homologous bacterin produced significant protection (80%). Immunoblotting showed that the experimental vaccine elicited more specific antibodies against C. jejuni clone SA. These findings strongly suggest the necessity of developing a homologous vaccine for the control C. jejuni clone SA induced abortion on sheep farms.
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页码：1 / 10
页数：10
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