Dopamine and the spinal cord in restless legs syndrome: Does spinal cord physiology reveal a basis for augmentation?

被引：45

作者：

Paulus, Walter

Schomburg, Eike D.

机构：

[1] Univ Gottingen, Dept Clin Neurophysiol, D-37075 Gottingen, Germany

[2] Univ Gottingen, Dept Neurophysiol, D-37075 Gottingen, Germany

来源：

SLEEP MEDICINE REVIEWS | 2006年 / 10卷 / 03期

关键词：

restless legs syndrome; spinal cord; dopamine; opioids; augmentation; cat; flexor reflex; state-dependent modulation;

D O I：

10.1016/j.smrv.2006.01.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The pathophysiology of restless legs syndrome (RLS) is incompletely understood. L-DOPA, as the precursor of dopamine, as well as dopamine agonists, plays an essential rote in the treatment of RLS leading to the assumption of a key role of dopamine function in the pathophysiology of RLS. Periodic limb movements in steep are a key feature of RLS. They are generated in the spinal cord. Here we review RLS phenomenology on the basis of known dopaminergic influence on spinal control, which has been studied a great deal in recent decades in animals. In particular, we propose that the differential effects Of L-DOPA and opioids on early and late flexor reflexes may be linked to the phenomenon of augmentation. (C) 2006 Published by Elsevier Ltd.

引用

页码：185 / 196

页数：12

共 63 条

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