Murine models to study Clostridium difficile infection and transmission

被引：24
作者：
Lawley, Trevor D. [1 ]
Young, Vincent B. [2 ,3 ]
机构：
[1] Wellcome Trust Sanger Inst, Bacterial Pathogenesis Lab, Cambridge CB10 1SA, England
[2] Univ Michigan, Dept Internal Med, Div Infect Dis, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA
来源：
ANAEROBE | 2013年 / 24卷
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
Clostridium difficile; Antibiotic-associated diarrhea; Disease; Transmission; Spore; Microbiota; ANTIBIOTIC PERTURBATION; GUT MICROBIOTA; COLITIS; DISEASE; SPORES; SUPPRESSION; DYNAMICS; HAMSTERS; DIARRHEA; GENE;
D O I：
10.1016/j.anaerobe.2013.09.008
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Clostridium difficile is the leading cause of antibiotic-associated diarrhea in healthcare facilities worldwide. C difficile infections are difficult to treat because of the high rate of disease recurrence after antibiotic therapy, leaving few treatment options for patients. C difficile is also difficult to contain within a healthcare setting due to a highly-transmissible, resistant spore form that challenges standard infection control measures. The recent development of murine infection models to study the interactions between C difficile, the host and the microbiota are providing novel insight into the mechanisms of pathogenesis and transmission that should guide the development of therapies and intervention measures. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：94 / 97
页数：4
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