Carbonic Anhydrase IX in Renal Cell Carcinoma, Implications for Disease Management

被引：53

作者：

Courcier, Jean ^{[1
,2
]}

de la Taille, Alexandre ^{[2
]}

Nourieh, Maya ^{[3
]}

Leguerney, Ingrid ^{[1
]}

Lassau, Nathalie ^{[1
,4
]}

Ingels, Alexandre ^{[1
,2
]}

机构：

[1] Univ Paris Saclay, Ctr Natl Rech Sci CNRS, Commissariat Energie Atom CEA, Biomaps,UMR1281,INSERM, F-94800 Villejuif, France

[2] Univ Paris Est Creteil UPEC, Henri Mondor Hosp, Dept Urol, F-94000 Creteil, France

[3] UPEC, Henri Mondor Hosp, Dept Pathol, F-94000 Creteil, France

[4] Inst Gustave Roussy, Dept Imaging, F-94800 Villejuif, France

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 19期

关键词：

carbonic anhydrase IX; renal cell carcinoma; clear cell; immunohistochemistry; molecular imaging; targeted therapy; MONOCLONAL-ANTIBODY GIRENTUXIMAB; MEMBRANE PROTEIN-A; INDEPENDENT PREDICTOR; EXPRESSION; CAIX; RADIOIMMUNOTHERAPY; GUIDELINES; PROGNOSIS; DIAGNOSIS; SURVIVAL;

D O I：

10.3390/ijms21197146

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carbonic Anhydrase IX (CAIX) is a well-described enzyme in renal cell carcinoma, with its expression being regulated by the hypoxia-inducible factor 1 alpha, it is known for interfering with hypoxia processes. Renal carcinoma encompasses a broad spectrum of histological entities and is also described as a heterogeneous malignant tumor. Recently, various combinations of checkpoint inhibitors and targeted therapies have been validated to manage this disease. Reliable markers to confirm the diagnosis, estimate the prognosis, predict or monitor the treatment response are required. Molecular imaging developments allow a comprehensive analysis of the tumor, overcoming the spatial heterogeneity issue. CAIX, being highly expressed at the tumor cell surfaces of clear cell renal carcinoma, also represents a potential treatment target. In this manuscript we reviewed the current knowledge from the literature on the pathophysiological interactions between renal cell carcinoma and CAIX, the role of CAIX as a marker for diagnosis, prognosis, treatment monitoring and molecular imaging, and the potential target for therapeutic strategies.

引用

页码：1 / 15

页数：15

共 58 条

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