The Schizosaccharomyces pombe cdc6 gene encodes the catalytic subunit of DNA polymerase delta

被引：17

作者：

Iino, Y ^{[1
]}

Yamamoto, M ^{[1
]}

机构：

[1] UNIV TOKYO,GRAD SCH SCI,DEPT BIOCHEM & BIOPHYS,TOKYO 113,JAPAN

来源：

MOLECULAR & GENERAL GENETICS | 1997年 / 254卷 / 01期

关键词：

Schizosaccharomyces pombe; cell cycle; cdc6; pol3; DNA polymerase delta;

D O I：

10.1007/s004380050395

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cdc6 mutants of Schizosaccharomyces pombe have been classified as being defective in progression through the G2 phase of the cell cycle. We cloned an S. pombe gene that could complement the temperature-sensitive growth of the cdc6-23 mutant. Unexpectedly, the cloned gene was allelic to pol3, which encodes the catalytic subunit of DNA polymerase gamma. Integration mapping confirmed that cdc6 and pol3 are identical. The cdc6-23 mutant carries one amino acid substitution in the conserved N3 region of Pol3.

引用

页码：93 / 97

页数：5

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