Enantioselective synthesis of substituted pyrrolidines by dynamic resolution

被引：0
|
作者：
Coldham, I
Dufour, S
Haxell, TFN
Howard, S
Vennall, GP
机构：
[1] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England
[2] GlaxoSmithKline, Harlow CM19 5AW, Essex, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 20期
关键词：
amines; carbanions; dynamic resolution; enantioselectivity; lithiation;
D O I：
10.1002/1521-3773(20021018)41:20<3887::AID-ANIE3887>3.0.CO;2-J
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Not restricted to allylic or benzylic derivatives: The dynamic resolution of chiral organolithium species in the presence of a chiral ligand, L*, followed by addition of an electrophile, E+ (see scheme), has been shown to occur with excellent enantioselectivity at ambient temperature by using nonactivated 2-lithiopyrrolidines.
引用
收藏
页码：3887 / 3889
页数：3
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