Stereoselective synthesis of the C1-C20 segment of the microsclerodermins A and B

被引：11

作者：

Chandrasekhar, S. ^{[1
]}

Sultana, S. Shameem ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 40期

关键词：

stereoselective; deoxygenative rearrangement; Iterative Sharpless asymmetric dihydroxylation; ANTIFUNGAL CYCLIC-PEPTIDES; ACID; ISOMERIZATION; AMINO;

D O I：

10.1016/j.tetlet.2006.07.107

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective route for the synthesis of key fragment Cl-C20 resident in microsclerodermins A and B is described. The route features deoxygenative rearrangement of an hydroxy-alkynoate and a highly enantio- and diastereo-controled iterative dihydroxylation as key reactions, starting from S-( - )-citronellol. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：7255 / 7258

页数：4

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