6-Mercaptopurine/Azathioprine remains an important contributor in managing Crohn's disease

被引:3
作者
Korelitz, Burton I. [1 ,2 ]
Present, Daniel H. [3 ]
机构
[1] Lenox Hill Hosp, New York, NY 10075 USA
[2] NYU, Sch Med, New York, NY 10003 USA
[3] Mt Sinai Hosp, ICAHN Sch Med, New York, NY 10029 USA
关键词
Crohn's disease; 6-Mercaptopurine; Azathioprine; INFLAMMATORY-BOWEL-DISEASE; LONG-TERM; AZATHIOPRINE; TRIAL; MANAGEMENT; THERAPY; PLACEBO; COLITIS; CANCER; RISK;
D O I
10.1016/j.crohns.2013.12.024
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Two large studies concluded that AZA started early after diagnosis of Crohn's disease have no late maintenance value. This is contrary to previous studies on 6MP for Crohn's disease and could lead to negating the value of two of the few drugs that have been proven successful. We here outline the many reasons why 6MP remains a valuable drug in the treatment of Crohn's disease. (c) 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:735 / 738
页数:4
相关论文
共 21 条
[1]   Anorectal Crohn's disease - Surgical and medical management [J].
Aronoff, JS ;
Korelitz, BI ;
Sohn, N ;
Ky, A ;
Rajapakse, R ;
Weinstein, MA ;
Cohen, FS .
BIODRUGS, 2000, 13 (02) :95-105
[2]   Risk of Colorectal High-Grade Dysplasia and Cancer in a Prospective Observational Cohort of Patients With Inflammatory Bowel Disease [J].
Beaugerie, Laurent ;
Svrcek, Magali ;
Seksik, Philippe ;
Bouvier, Anne-Marie ;
Simon, Tabassome ;
Allez, Matthieu ;
Brixi, Hedia ;
Gornet, Jean-Marc ;
Altwegg, Romain ;
Beau, Philippe ;
Duclos, Bernard ;
Bourreille, Arnaud ;
Faivre, Jean ;
Peyrin-Biroulet, Laurent ;
Flejou, Jean-Francois ;
Carrat, Fabrice .
GASTROENTEROLOGY, 2013, 145 (01) :166-+
[3]  
BEST WR, 1976, GASTROENTEROLOGY, V70, P439
[4]   Long-term Outcome of Patients With Crohn's Disease Who Respond to Azathioprine [J].
Camus, Marine ;
Seksik, Philippe ;
Bourrier, Anne ;
Nion-Larmurier, Isabelle ;
Sokol, Harry ;
Baumer, Philippe ;
Beaugerie, Laurent ;
Cosnes, Jacques .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2013, 11 (04) :389-394
[5]   Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease. [J].
Colombel, Jean Frederic ;
Sandborn, William J. ;
Reinisch, Walter ;
Mantzaris, Gerassimos J. ;
Kornbluth, Asher ;
Rachmilewitz, Daniel ;
Lichtiger, Simon ;
D'Haens, Geert ;
Diamond, Robert H. ;
Broussard, Delma L. ;
Tang, Kezhen L. ;
van der Woude, C. Janneke ;
Rutgeerts, Paul .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (15) :1383-1395
[6]   Early Administration of Azathioprine vs Conventional Management of Crohn's Disease: A Randomized Controlled Trial [J].
Cosnes, Jacques ;
Bourrier, Anne ;
Laharie, David ;
Nahon, Stephane ;
Bouhnik, Yoram ;
Carbonnel, Franck ;
Allez, Matthieu ;
Dupas, Jean-Louis ;
Reimund, Jean-Marie ;
Savoye, Guillaume ;
Jouet, Pauline ;
Moreau, Jacques ;
Mary, Jean-Yves ;
Colombel, Jean-Frederic .
GASTROENTEROLOGY, 2013, 145 (04) :758-+
[7]   NATURE AND COURSE OF PANCREATITIS CAUSED BY 6-MERCAPTOPURINE IN THE TREATMENT OF INFLAMMATORY BOWEL-DISEASE [J].
HABER, CJ ;
MELTZER, SJ ;
PRESENT, DH ;
KORELITZ, BI .
GASTROENTEROLOGY, 1986, 91 (04) :982-986
[8]   Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo: A 2-year trial [J].
Hanauer, SB ;
Korelitz, BI ;
Rutgeerts, P ;
Peppercorn, MA ;
Thisted, RA ;
Cohen, RD ;
Present, DH .
GASTROENTEROLOGY, 2004, 127 (03) :723-729
[9]   Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine [J].
Kandiel, A ;
Fraser, AG ;
Korelitz, BI ;
Brensinger, C ;
Lewis, JD .
GUT, 2005, 54 (08) :1121-1125
[10]  
KORELITZ BI, 1981, GASTROENTEROLOGY, V80, P193