Dengue diagnosis, advances and challenges

被引：223

作者：

Guzmán, MG ^{[1
]}

Kourí, G ^{[1
]}

机构：

[1] Pedro Kouri Trop Med Inst, PAHO WHO Collaborating Ctr Viral Dis, Dept Virol, Havana, Cuba

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2004年 / 8卷 / 02期

关键词：

Dengue; Dengue hemorrhagic; fever; diagnosis;

D O I：

10.1016/j.ijid.2003.03.003

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Dengue diagnosis was one of the topics discussed at the symposium 'The Global Threat of Dengue - Desperately Seeking Solutions' organized during the 10th International Congress of Infectious Diseases held in Singapore in 2002. In this paper, a review is presented focusing on the main advances, problems and challenges of dengue diagnosis. IgM capture ELISA, virus isolation in mosquito cell tines and live mosquitoes, dengue specific monoclonal antibodies and PCR have all represented major advances in dengue diagnosis. However, an appropriate rapid, early and accessible diagnostic method useful both for epidemiological surveillance and clinical diagnosis is still needed. Also, tools that suggest a prognosis allowing for better management are also needed. Finally, laboratory infrastructure, technical expertise and research capacity must be improved in endemic countries in order to positively influence dengue surveillance, clinical case management and the development of new approaches to dengue control. (C) 2003 International Society for Infectious Diseases. Published by Elsevier Ltd. AR rights reserved.

引用

页码：69 / 80

页数：12

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