Posaconazole Concentrations in Human Tissues after Allogeneic Stem Cell Transplantation

被引：20

作者：

Blennow, Ola ^{[1
,5
]}

Eliasson, Erik ^{[2
]}

Pettersson, Tommy ^{[2
]}

Pohanka, Anton ^{[2
]}

Szakos, Attila ^{[3
]}

El-Serafi, Ibrahim ^{[4
]}

Hassan, Moustapha ^{[4
]}

Ringden, Olle ^{[5
]}

Mattsson, Jonas ^{[5
]}

机构：

[1] Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden

[2] Karolinska Inst, Karolinska Univ Hosp Huddinge, Div Clin Pharmacol, Dept Lab Med, Stockholm, Sweden

[3] Karolinska Univ Hosp, Dept Clin Pathol & Cytol, Stockholm, Sweden

[4] Karolinska Inst, Dept Lab Med, Clin Res Ctr, Stockholm, Sweden

[5] Karolinska Univ Hosp, Ctr Allogene Stem Cell Transplantat, Stockholm, Sweden

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 08期

基金：

瑞典研究理事会;

关键词：

EXPOSURE-RESPONSE RELATIONSHIP; INTRAPULMONARY PHARMACOKINETICS; STEADY-STATE; PROPHYLAXIS; FLUCONAZOLE; PHARMACODYNAMICS; ITRACONAZOLE;

D O I：

10.1128/AAC.03252-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Few data have been published regarding posaconazole tissue concentrations in humans. We analyzed tissue concentrations in biopsy specimens taken at autopsy from seven patients who received posaconazole prophylaxis because of graft-versus-host disease. The results were compared to plasma concentrations collected before death. Tissue concentrations suggestive of an accumulation of posaconazole were found in the heart, lung, liver, and kidney but not in the brain.

引用

页码：4941 / 4943

页数：3

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