Synapsin III gene polymorphisms and schizophrenia

被引：21

作者：

Ohmori, O ^{[1
]}

Shinkai, T ^{[1
]}

Hori, H ^{[1
]}

Kojima, H ^{[1
]}

Nakamura, J ^{[1
]}

机构：

[1] Univ Occupat & Environm Hlth, Sch Med, Dept Psychiat, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan

来源：

NEUROSCIENCE LETTERS | 2000年 / 279卷 / 02期

关键词：

schizophrenia; synapsins; synapsin III; polymorphism; genetic association; chromosome; 22;

D O I：

10.1016/S0304-3940(99)00970-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Synapsins are synaptic vesicle-associated phosphoproteins and are thought to play crucial roles in synaptogenesis and neurotransmitter release. Synaptic abnormalities have been reported in the pathophysiology of schizophrenia. In addition, the synapsin III gene, a member of the synapsin gene family, has been located at 22q12-13, which has been suggested as a potential susceptibility locus for schizophrenia. We investigated a genetic association between schizophrenia and the synapsin III gene polymorphisms (-631C/G and -196G/A) in 160 schizophrenic patients and 153 controls. No significant positive association between either polymorphism and schizophrenia was observed. Furthermore, no significant association was observed between either polymorphism and the diagnostic subtypes. Our results suggested that the synapsin III gene polymorphisms do not confer increased susceptibility to schizophrenia. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：125 / 127

页数：3

共 23 条

[1] Synaptic degeneration in thalamus in schizophrenia [J].