Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.

被引：20

作者：

Iwasaki, Arihiro ^{[1
]}

Ohno, Osamu ^{[1
]}

Sumimoto, Shinpei ^{[2
]}

Suda, Shoichiro ^{[2
]}

Suenaga, Kiyotake ^{[1
]}

机构：

[1] Keio Univ, Dept Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

[2] Univ Ryukyus, Fac Sci, Nishihara, Okinawa 9030213, Japan

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 30期

关键词：

Maedamide; Marine cyanobacteria; Depsipeptide; Chymotrypsin inhibitor; Lyngbya; POTENT ELASTASE INHIBITORS;

D O I：

10.1016/j.tetlet.2014.05.099

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Maedamide, a novel chymotrypsin-inhibiting depsipeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Maedamide selectively inhibited chymotrypsin but not elastase and trypsin. In addition, Maedamide strongly inhibited the growth of HeLa cells and HL60 cells. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：4126 / 4128

页数：3

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