The role of the bax gene polymorphism G(-248) A in chronic lymphocytic leukemia

被引:13
作者
Fegan, C. [1 ]
Starczynski, J.
Pratt, G.
Pepper, C.
机构
[1] Cardiff Univ, Wales Sch Med, Dept Haematol, Cardiff, Wales
[2] Heart Engn NHS Trust, Dept Haematol, Birmingham, W Midlands, England
[3] Univ Birmingham, Inst Canc Res, Birmingham B15 2TT, W Midlands, England
[4] Llandough Hosp, Dept Haematol, Penarth, S Glam, Wales
关键词
D O I
10.1038/sj.leu.2404280
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1460 / 1461
页数:3
相关论文
共 5 条
[1]   Bax gene G(-248)A promoter polymorphism and chronic lymphocytic leukemia:: lack of association with incidence, disease stage and progression-free survival [J].
Nueckel, H ;
Frey, UH ;
Sellmann, L ;
Bau, M ;
Duerig, J ;
Duehrsen, U ;
Siffert, W .
LEUKEMIA, 2006, 20 (04) :724-724
[2]   Chlorambucil resistance in B-cell chronic lymphocytic leukaemia is mediated through failed Bax induction and selection of high Bcl-2-expressing subclones [J].
Pepper, C ;
Thomas, A ;
Hoy, T ;
Bentley, P .
BRITISH JOURNAL OF HAEMATOLOGY, 1999, 104 (03) :581-588
[3]   Association of a novel single nucleotide polymorphism, G(-248)A, in the 5′-UTR of BAX gene in chronic lymphocytic leukemia with disease progression and treatment resistance [J].
Saxena, A ;
Moshynska, O ;
Sankaran, K ;
Viswanathan, S ;
Sheridan, DP .
CANCER LETTERS, 2002, 187 (1-2) :199-205
[4]   The G(-248)A polymorphism in the promoter region of the Bax gene does not correlate with prognostic markers or overall survival in chronic lymphocytic leukemia [J].
Skogsberg, Å ;
Tobin, G ;
Kröber, A ;
Kienle, D ;
Thunberg, U ;
Åleskog, A ;
Karlsson, K ;
Laurell, A ;
Merup, M ;
Vilpo, J ;
Sundström, C ;
Roos, G ;
Jernerg-Wiklund, H ;
Döhner, H ;
Nilsson, K ;
Stilgenbauer, S ;
Rosenquist, R .
LEUKEMIA, 2006, 20 (01) :77-81
[5]   Common polymorphism G(-248)A in the promoter region of the bax gene results in significantly shorter survival in patients with chronic lymphocytic leukemia once treatment is initiated [J].
Starczynski, J ;
Pepper, C ;
Pratt, G ;
Hooper, L ;
Thomas, A ;
Milligan, D ;
Bentley, P ;
Fegan, C .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (07) :1514-1521