The Clinical Impacts of Pretreatment Peripheral Blood Ratio on Lymphocytes, Monocytes, and Neutrophils Among Patients with Laryngeal/Hypopharyngeal Cancer Treated by Chemoradiation/Radiation

被引：8

作者：

Chuang, Hui-Ching ^{[1
,2
,3
]}

Tsai, Ming-Hsien ^{[1
,2
,3
]}

Lin, Yu-Tsai ^{[1
,2
,3
]}

Chou, Ming-Huei ^{[4
,5
]}

Huang, Tai-Lin ^{[2
,3
,6
]}

Chiu, Tai-Jan ^{[2
,3
,6
]}

Lu, Hui ^{[1
,2
]}

Fang, Fu-Min ^{[2
,3
,7
]}

Chien, Chih-Yen ^{[1
,2
,3
,8
]}

机构：

[1] Kaohsiung Chang Gung Mem Hosp, Dept Otolaryngol, Kaohsiung, Taiwan

[2] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan

[3] Kaohsiung Chang Gung Mem Hosp, Canc Ctr, Kaohsiung Chang Gung Head & Neck Oncol Grp, Kaohsiung, Taiwan

[4] Chang Gung Univ, Grad Inst Clin Med Sci, Coll Med, Kaohsiung, Taiwan

[5] Cheng Shiu Univ, Ctr Gen Educ, Kaohsiung, Taiwan

[6] Kaohsiung Chang Gung Mem Hosp, Dept Hematol Oncol, Kaohsiung, Taiwan

[7] Kaohsiung Chang Gung Mem Hosp, Dept Radiat Oncol, Kaohsiung, Taiwan

[8] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung, Taiwan

来源：

CANCER MANAGEMENT AND RESEARCH | 2020年 / 12卷

关键词：

head and neck squamous cell carcinoma; hypopharyngeal cancer; laryngeal cancer; systemic inflammation response index; neutrophil-lymphocyte ratio; lymphocyte monocyte ratio; LOW PREOPERATIVE LYMPHOCYTE; RESPONSE INDEX SIRI; CELL CARCINOMA; PROGNOSTIC-FACTOR; HEAD; MACROPHAGES; SURVIVAL; MELANOMA; OUTCOMES; MARKERS;

D O I：

10.2147/CMAR.S275635

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: This study aimed to investigate the clinical impacts of the pretreatment peripheral blood ratios of lymphocytes, monocytes and neutrophils among patients with hypopharyngeal cancer/laryngeal cancer. Patients and Methods: A total of 141 people with cases of hypopharyngeal cancer/ laryngeal cancer were enrolled to evaluate the clinical impacts of the systemic inflammation response index (SIRI), neutrophil-lymphocyte ratio (NLR) and lymphocyte-monocyte ratio (LMR) in pretreatment blood among patients with laryngeal/hypopharyngeal cancer between January 2012 and December 2014. Results: Those patients with higher pretreatment LMR ( 2.99) showed a significantly higher 5-year complete response rate (CR) (69% vs 31%) than those with lower LMR (<= 2.99, p = 0.006). Additionally, those patients with lower pretreatment SIRI (<3.26) showed a significantly higher 5-year CR (90% vs 10%) than those with higher SIRI (>= 3.26, p < 0.001). Patients with higher LMR had better 5-year overall survival (OS) (p = 0.01) and 5-year progression-free (PFS) (p = 0.005) rates than those with lower LMR in univariate analysis. Patients with lower SIRI had better 5-year OS (p < 0.001) and 5-year PFS (p < 0.001) than those with higher SIRI in univariate analysis. In the Cox regression analysis, SIRI (HR = 1.941, [95% CI: 1.223-3.081], p = 0.005) and N classification (HR = 2.203, [95% CI: 1.327-3.657], p = 0.002) were independent variables of 5-year OS. In addition, SIRI (HR= 2.127, [95% CI: 1.214-3.725], p = 0.008), T classification (HR = 2.18, [95% CI: 1.072-4.433], p = 0.031), and N classification (HR = 2.329, [95% CI: 1.395-3.889], p = 0.001) were independent variables of 5-year PFS. Conclusion: Pretreatment SIRI is superior to LMR in predicting treatment response and clinical outcomes among patients with laryngeal/hypopharyngeal cancer treated by CRT/RTO. SIRI may be adopted in the treatment of laryngeal/hypopharyngeal cancer by CRT/RTO.

引用

页码：9013 / 9021

页数：9

共 33 条

[1] Decreased pretreatment lymphocyte/monocyte ratio is associated with poor prognosis in stage Ib1-IIa cervical cancer patients who undergo radical surgery [J].