High incidence of pulmonary toxicity of weekly docetaxel and gemcitabine in patients with non-small cell lung cancer: results of a dose-finding study

被引:57
作者
Kouroussis, C [1 ]
Mavroudis, D [1 ]
Kakolyris, S [1 ]
Voloudaki, A [1 ]
Kalbakis, K [1 ]
Souglakos, J [1 ]
Agelaki, S [1 ]
Malas, K [1 ]
Bozionelou, V [1 ]
Georgoulias, V [1 ]
机构
[1] Univ Heraklion, Gen Hosp, Dept Med Oncol, Iraklion 71110, Crete, Greece
关键词
docetaxel; gemcitabine; pulmonary toxicity;
D O I
10.1016/j.lungcan.2003.12.004
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: To determine the maximum tolerated doses (MTD) and the dose-limiting toxicities (DLTs) of the weekly administration of docetaxel and gemcitabine as first-line treatment in patients with advanced non-small cell lung cancer (NSCLC). Patients and methods: Chemotherapy-naive patients with histologically or cytologically confirmed unresectable stage IIIB or IV NSCLC were enrolled onto the study. Escalated doses of gemcitabine (starting dose 700 mg/m(2) per week) and docetaxel (starting dose 30 mg/m(2) per week) were given on a weekly basis for three consecutive weeks in cycles of 4 weeks. Results: Twenty-six patients received a total of 94 chemotherapy cycles. At the doses of docetaxel 40 mg/m2 per week and gemcitabine 1000 mg/m(2) per week, the MTD had not yet been reached. However, the study was prematurely closed because of a high incidence of severe pulmonary adverse events. Six (23%) patients developed fever and pulmonary dysfunction (severe dyspnea, hypoxia in association with diffuse interstitial pneumonitis), which was fatal in two of them. No risk factors were identified contributing to these pulmonary adverse events; four patients had a low absolute number of peripheral blood CD4+ lymphocytes. Grade 3/4 neutropenia occurred in five (19%) patients and grade 3/4 anemia in two (8%). Conclusion: The weekly administration of gemcitabine and docetaxel in patients with advanced NSCLC is associated with a high incidence of severe pulmonary toxicity, which does not seem to be dose-related. The regimen cannot be used outside a clinical protocol. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:363 / 368
页数:6
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