BANFF: bending of bilayer membranes by amphiphilic α-helices is necessary for form and function of organelles

被引：3

作者：

Koennel, Anne ^{[1
]}

Bugaeva, Wassilina ^{[1
]}

Guegel, Irene L. ^{[2
,3
]}

Philippar, Katrin ^{[1
]}

机构：

[1] Saarland Univ, Ctr Human & Mol Biol ZHMB Plant Biol, Campus A 2-4, D-66123 Saarbrucken, Germany

[2] Ludwig Maximilians Univ Munchen, Dept Biol Bot 1, Grosshaderner Str 2, D-82152 Planegg Martinsried, Germany

[3] Ctr Adv European Studies & Res Computat Neurethol, Ludwig Erhard Allee 2, D-53175 Bonn, Germany

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 2019年 / 97卷 / 03期

关键词：

amphiphilic alpha-helix; membrane curvature; mitochondrium; chloroplast; fatty acid/lipid transport; MITOCHONDRIAL CONTACT SITE; CRISTAE ORGANIZING SYSTEM; CHLOROPLASTIC OUTER ENVELOPE; LIPID TRAFFICKING; SOLUTE CHANNEL; FATTY-ACIDS; ENDOPLASMIC-RETICULUM; THYLAKOID MEMBRANES; BINDING-PROTEINS; CURVATURE;

D O I：

10.1139/bcb-2018-0150

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By binding to and inserting into the lipid bilayer, amphiphilic alpha-helices of proteins are involved in the curvature of biological membranes in all organisms. In particular, they are involved in establishing the complex membrane architecture of intracellular organelles like the endoplasmatic reticulum, Golgi apparatus, mitochondria, and chloroplasts. Thus, amphiphilic alpha-helices are essential for maintenance of cellular metabolism and fitness of organisms. Here we focus on the structure and function of membrane-intrinsic proteins, which are involved in membrane curvature by amphiphilic alpha-helices, in mitochondria and chloroplasts of the eukaryotic model organisms yeast and Arabidopsis thaliana. Further, we propose a model for transport of fatty acids and lipid compounds across the envelope of chloroplasts in which amphiphilic alpha-helices might play a role.

引用

页码：243 / 256

页数：14