Genetic controls of susceptibility and resistance to 4-nitroquinoline 1-oxide-induced tongue carcinomas in rats

被引：13

作者：

Kitano, M

Hirayama, Y

Tanuma, J

Matsuuchi, H

Miura, Y

Li, TJ

Semba, I

Ozaki, HS

Kokubu, T

Hatano, H

Tada, M

Kobayashi, Y

Shisa, H

机构：

[1] KAGOSHIMA UNIV,SCH DENT,DEPT ORAL ANAT,KAGOSHIMA 890,JAPAN

[2] KAGOSHIMA UNIV,DEPT AGR SCI & NAT RESOURCES,FAC AGR,KAGOSHIMA 890,JAPAN

[3] KURUME UNIV,FAC MED,SCH NURSING,KURUME,FUKUOKA 830,JAPAN

[4] AICHI CANC CTR,RES INST,DEPT BIOCHEM,CHIGUSA KU,NAGOYA,AICHI 464,JAPAN

[5] SAITAMA CANC CTR,RES INST,DEPT PATHOL,INA,SAITAMA 362,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1996年 / 87卷 / 11期

关键词：

4-nitroquinoline; 1-oxide; tongue carcinoma; susceptibility; resistance; genetic control;

D O I：

10.1111/j.1349-7006.1996.tb03116.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We analyzed the incidence of infiltrative mass-type tongue carcinomas (IMTC) induced in 550 rats by continuous oral administration of 0.001% 4-nitroquinoline 1-oxide solution for 180 days. The study included various crosses of susceptible Dark-Agouti rats (DA) and resistant Wistar/Furth rats (WF), DA showed a 93.6% incidence of IMTC measuring more than 5 mm in their largest diameter, while WF showed only a 4% incidence. Reciprocal F-1 and F-2 hybrids mated by DA and WF showed 47.5% and 45.8% incidences, respectively. Meanwhile, reciprocal backcrossed hybrids to DA and WF showed 73.7%, and 24.6% incidences, respectively. Segregation of the incidences suggests that there are two autosomal dominant genes, one linked to the susceptibility of DA and the other to the resistance of WF.

引用

页码：1097 / 1101

页数：5

共 16 条

[1] DIFFERENTIAL ACTIVITY OF HUMAN, RAT, MOUSE AND BACTERIA GLUTATHIONE TRANSFERASE ISOENZYMES TOWARDS 4-NITROQUINOLINE 1-OXIDE [J].