Targeting IL-4 for the Treatment of Atopic Dermatitis

被引：0
|
作者：
Chiricozzi, Andrea [1 ,2 ]
Maurelli, Martina [3 ]
Peris, Ketty [1 ,2 ]
Girolomoni, Giampiero [3 ]
机构：
[1] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Med & Chirurg, Dermatol, I-00168 Rome, Italy
[2] Univ Cattolica Sacro Cuore, Dermatol, Rome, Italy
[3] Univ Verona, Dept Med, Sect Dermatol, Verona, Italy
来源：
IMMUNOTARGETS AND THERAPY | 2020年 / 9卷
关键词：
atopic dermatitis; IL-4; inhibitor; dupilumab; pascolizumab; pitrakinra; TH2; CYTOKINES; STAPHYLOCOCCUS-AUREUS; DERMAL FIBROBLASTS; DENDRITIC CELLS; TRANSGENIC MICE; LESIONAL SKIN; UP-REGULATION; IFN-GAMMA; IN-VITRO; T-CELLS;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Atopic dermatitis (AD) is an immune-mediated inflammatory skin disease characterized by a predominant type 2 immune response. Type 2 immunity is driven by multiple cytokines, including interleukin (IL)-4 and IL-13 that are considered central to AD pathogenesis and key therapeutic targets. The dual inhibition of these two cytokines or the selective inhibition of IL-13 proved elevated efficacy in treating AD, whereas the selective inhibition of IL-4 has been poorly investigated as IL-4 inhibiting agents did not show any advance in clinical development programs. This review describes the pathogenic role of IL-4 in AD and briefly resumes the main features of compounds selectively blocking IL-4.
引用
收藏
页码：151 / 156
页数：6
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