Targeting IL-4 for the Treatment of Atopic Dermatitis

被引：0
|
作者：
Chiricozzi, Andrea [1 ,2 ]
Maurelli, Martina [3 ]
Peris, Ketty [1 ,2 ]
Girolomoni, Giampiero [3 ]
机构：
[1] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Med & Chirurg, Dermatol, I-00168 Rome, Italy
[2] Univ Cattolica Sacro Cuore, Dermatol, Rome, Italy
[3] Univ Verona, Dept Med, Sect Dermatol, Verona, Italy
来源：
IMMUNOTARGETS AND THERAPY | 2020年 / 9卷
关键词：
atopic dermatitis; IL-4; inhibitor; dupilumab; pascolizumab; pitrakinra; TH2; CYTOKINES; STAPHYLOCOCCUS-AUREUS; DERMAL FIBROBLASTS; DENDRITIC CELLS; TRANSGENIC MICE; LESIONAL SKIN; UP-REGULATION; IFN-GAMMA; IN-VITRO; T-CELLS;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Atopic dermatitis (AD) is an immune-mediated inflammatory skin disease characterized by a predominant type 2 immune response. Type 2 immunity is driven by multiple cytokines, including interleukin (IL)-4 and IL-13 that are considered central to AD pathogenesis and key therapeutic targets. The dual inhibition of these two cytokines or the selective inhibition of IL-13 proved elevated efficacy in treating AD, whereas the selective inhibition of IL-4 has been poorly investigated as IL-4 inhibiting agents did not show any advance in clinical development programs. This review describes the pathogenic role of IL-4 in AD and briefly resumes the main features of compounds selectively blocking IL-4.
引用
收藏
页码：151 / 156
页数：6
相关论文
共 50 条
  • [31] IL-4 INDUCES CHEMOTAXIS OF BLOOD EOSINOPHILS FROM ATOPIC-DERMATITIS PATIENTS, BUT NOT FROM NORMAL INDIVIDUALS
    DUBOIS, GR
    BRUIJNZEELKOOMEN, CAFM
    BRUIJNZEEL, PLB
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1994, 102 (06) : 843 - 846
  • [32] Ovalbumin-induced IL-4, IL-5 and IFN-γ production in infants with atopic dermatitis
    Kimura, M
    Obi, M
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2005, 137 (02) : 134 - 140
  • [33] Interleukin-13: Targeting an underestimated cytokine in atopic dermatitis
    Bieber, Thomas
    ALLERGY, 2020, 75 (01) : 54 - 62
  • [34] New pathogenic and therapeutic paradigms in atopic dermatitis
    Malajian, Dana
    Guttman-Yassky, Emma
    CYTOKINE, 2015, 73 (02) : 311 - 318
  • [35] Abnormal IL-4 gene expression by atopic dermatitis T lymphocytes is reflected in altered nuclear protein interactions with IL-4 transcriptional regulatory element
    Chan, SC
    Brown, MA
    Willcox, TM
    Li, SH
    Stevens, SR
    Tara, D
    Hanifin, JM
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1996, 106 (05) : 1131 - 1136
  • [36] A Narrative Review of the IL-18 and IL-37 Implications in the Pathogenesis of Atopic Dermatitis and Psoriasis: Prospective Treatment Targets
    Rusinol, Lluis
    Puig, Lluis
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (15)
  • [37] Adhesion molecule expression on skin endothelia in atopic dermatitis:: Effects of TNF-α and IL-4
    de Vries, IJM
    Langeveld-Wildschut, EG
    van Reijsen, FC
    Dubois, GR
    van den Hoek, JA
    Bihari, IC
    van Wichen, D
    de Weger, RA
    Knol, EF
    Thepen, T
    Bruijnzeel-Koomen, CAFM
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1998, 102 (03) : 461 - 468
  • [38] IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1, 2/Stat6 signal transduction pathway: Implication for atopic dermatitis
    Bao, Lei
    Shi, Vivian Y.
    Chan, Lawrence S.
    MOLECULAR IMMUNOLOGY, 2012, 50 (1-2) : 91 - 97
  • [39] Correlation of disease evolution with progressive inflammatory cell activation and migration in the IL-4 transgenic mouse model of atopic dermatitis
    Chen, L
    Martinez, O
    Venkataramani, P
    Lin, SX
    Prabhakar, BS
    Chan, LS
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2005, 139 (02) : 189 - 201
  • [40] Skin-infiltrating basophils promote atopic dermatitis-like inflammation via IL-4 production in mice
    Yamanishi, Yoshinori
    Mogi, Kotone
    Takahashi, Kazufusa
    Miyake, Kensuke
    Yoshikawa, Soichiro
    Karasuyama, Hajime
    ALLERGY, 2020, 75 (10) : 2613 - 2622
12345