Gastrointestinal motility, dysbiosis and opioid-induced tolerance: is there a link?

被引：39

作者：

Akbarali, Hamid I. ^{[1
]}

Dewey, William L. ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Richmond, VA 23284 USA

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2019年 / 16卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/s41575-019-0150-x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Studies show that gut microbial dysbiosis induced by chronic opioid use is linked to central opioid tolerance. Here, we suggest that a persistent decrease in gastrointestinal motility by opioids is a primary cause of gut microbial dysbiosis and that improving gastrointestinal transit might be a strategy in preventing opioid analgesic tolerance.

引用

页码：323 / 324

页数：2

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