Single-Molecule Test for Markovianity of the Dynamics along a Reaction Coordinate

被引：35

作者：

Berezhkovskii, Alexander M. ^{[1
]}

Makarov, Dmitrii E. ^{[2
,3
]}

机构：

[1] NIH, Math & Stat Comp Lab, Off Intramural Res, Ctr Informat Technol, Bethesda, MD 20892 USA

[2] Univ Texas Austin, Dept Chem, Austin, TX 78712 USA

[3] Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY LETTERS | 2018年 / 9卷 / 09期

基金：

美国国家科学基金会;

关键词：

ACTIVATED RATE-PROCESSES; CONFORMATIONAL MEMORY; ENERGY LANDSCAPES; TRANSITION PATHS; DIFFUSION; PROTEINS; KINETICS; SIMULATION; HAIRPIN; KRAMERS;

D O I：

10.1021/acs.jpclett.8b00956

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In an effort to answer the much-debated question of whether the time evolution of common experimental observables can be described as one-dimensional diffusion in the potential of mean force, we propose a simple criterion that allows one to test whether the Markov assumption is applicable to a single-molecule trajectory x(t). This test does not involve fitting of the data to any presupposed model and can be applied to experimental data with relatively low temporal resolution.

引用

页码：2190 / 2195

页数：11

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