Arthropod-derived histamine-binding protein prevents murine allergic asthma

被引：36

作者：

Couillin, I

Maillet, I

Vargaftig, BB

Jacobs, M

Paesen, GC

Nuttall, PA

Lefort, J

Moser, R

Weston-Davies, W

Ryffel, B ^{[1
]}

机构：

[1] CNRS, Inst Transgenose, F-41500 Orleans, France

[2] Key Obs SA, Orleans, France

[3] Evolutec Ltd, Oxford, England

[4] Ctr Ecol& Hydrol, Oxford, England

[5] Univ Sao Paulo, Dept Pharmacol, Inst Ciencias Biomed, Sao Paulo, Brazil

[6] Inst Biopharmaceut Res, Matzingen, Switzerland

来源：

JOURNAL OF IMMUNOLOGY | 2004年 / 173卷 / 05期

关键词：

D O I：

10.4049/jimmunol.173.5.3281

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Because histamine receptor type I blockade attenuates allergic asthma, we asked whether complete neutralization of histamine by an arthropod-derived, high affinity histamine-binding protein (EV131) would prevent allergic asthma. Intranasal administration of EV131 given before Ag challenge in immunized mice prevented airway hyperreactivity by 70%, and abrogated peribronchial inflammation, pulmonary eosinophilia, mucus hypersecretion, and IL-4 and IL-5 secretion. Saturation with histamine abrogated the inhibitory effect of EV131 on bronchial hyperreactivity. The inhibitory effect of EV131 on bronchial hyperreactivity was comparable to that of glucocorticosteroids. These results demonstrate that histamine is a critical mediator of allergic asthma. Therefore, complete neutralization of histamine, rather than specific histamine receptor blockade, may have a profound effect on allergic asthma.

引用

页码：3281 / 3286

页数：6

共 39 条

[1]

Bachert C, 1998, CLIN EXP ALLERGY, V28, P15

[2] Histamine polarizes human dendritic cells into Th2 cell-promoting effector dendritic cells [J].