Disseminated Penicillium radicum infection in a dog, clinically resembling multicentric malignant lymphoma

被引：13

作者：

de Vos, J. P. ^{[1
,6
]}

van Garderen, E. ^{[2
]}

Hensen, H. ^{[3
]}

Tange, I. ^{[4
]}

Curfs-Breuker, I. ^{[5
]}

Vandevelde, B. ^{[1
,6
]}

Meis, J. F. ^{[5
]}

机构：

[1] Clin Compan Anim Med, Diemenstr 83, NL-4535 AR Terneuzen, Netherlands

[2] Anim Hlth Serv, Lab Pathol & Histol, NL-7400 AA Deventer, Netherlands

[3] Vet Clin IJzendijke, NL-4515 BC Ijzendijke, Netherlands

[4] Zorgsaam Fdn Zeeuws Vlaanderen, Lab Med Microbiol, NL-4535 PA Terneuzen, Netherlands

[5] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, NL-6532 SZ Nijmegen, Netherlands

[6] Vet Oncol Referral Ctr, NL-4535 AR Terneuzen, Netherlands

来源：

VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT | 2009年 / 78卷 / 03期

关键词：

HYPERCALCEMIA; PICEUM;

D O I：

10.21825/vdt.87513

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

After detecting fungal organisms in smears of enlarged peripheral lymph nodes in a dog, determination was performed through culturing and genetic typing. The fungus was identified as Penicillium radicum by amplification of fungal DNA encoding of the ribosomal internal transcribed spacer region and comparison with DNA databases. In vitro susceptibility testing revealed multiresistance. In the literature, P. radicum is mentioned as a phosphate solubilizing agent used in agriculture for promoting plant growth. This is the first publication of a disseminated P. radicum infection in a dog. The generalized lymphadenopathy and hypercalcemia strongly resembled a multicentric lymphoma. Hypercalcemia in granulomatous diseases, including disseminated fungal infections, is caused by activated macrophages possessing 1 alpha-hydroxylase, which is able to convert 25-hydroxyvitamin-D into calcitriol. Although disseminated fungal infections are extremely rare in The Netherlands and Belgium, they, should be included in the differential diagnosis of dogs with multicentric lymphadenopathy and hypercalcemia.

引用

页码：183 / 188

页数：6

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