Enantiomeric separation of five basic drugs with cyclodextrins as chiral additive by capillary electrophoresis

A study of enantiomeric separation of five racemic basic drugs of pharmaceutical interest and with similar chiral center structure by cyclodextrins modified capillary electrophoresis was presented. The effect about the type of cyclodextrins and their derivatives, alpha-, beta-, gamma-cyclodextrin, 2,6-O-dimethyl, 2, 3, 6-O-trimethyl, and 2-O-hydroxypropyl-beta-cyclodextrin, as chiral selector was discussed. The concentration of cyclodextrins additives to achieve a suitable separation was optimized experimentally. The influence of applied voltage, operation temperature, pH and ion strength of background electrolyte was investigated in detail.