Radiolysis of 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) and the role of ethanol and radioactive concentration

被引：36

作者：

Jacobson, Mark S. ^{[1
]}

Dankwart, Heather R. ^{[1
]}

Mahoney, Douglas W. ^{[2
]}

机构：

[1] Mayo Clin, Div Nucl Med, Rochester, MN 55905 USA

[2] Mayo Clin, Div Biostat, Rochester, MN 55905 USA

来源：

APPLIED RADIATION AND ISOTOPES | 2009年 / 67卷 / 06期

关键词：

PET RADIOPHARMACEUTICALS; STABILITY; DECOMPOSITION; EPIMERIZATION; TRITIUM; FDG;

D O I：

10.1016/j.apradiso.2009.01.005

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Radiolysis is the process by which radioactively labeled compounds degrade. Many positron emission tomography (PET) radiopharmaceuticals produced with high radioactive concentrations and specific activities exhibit low radiochemical purity because of radiolysis. Little data exist that describe the radiolytic decomposition of 2-[F-18]fluoro-2-deoxy-D-glucose ([F-18]FDG). The objective of our study was to profile the degradation of [F-18]FDG at various radioactive concentrations by measuring radiochemical purity at different time intervals and to study the effects of ethanol, a well-known reductant stabilizer of [F-18]FDG preparations. (C) 2009 Published by Elsevier Ltd.

引用

页码：990 / 995

页数：6

共 29 条

[1]

[Anonymous], US PHARM 31 NAT FORM

[2] STABILITY AND STORAGE OF COMPOUNDS LABELLED WITH RADIOISOTOPES [J].