Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

被引：609
|
作者：
Nilsson, J. [1 ,2 ]
Skog, J. [3 ,4 ,5 ]
Nordstrand, A. [2 ]
Baranov, V. [6 ]
Mincheva-Nilsson, L. [6 ]
Breakefield, X. O. [3 ,4 ,5 ]
Widmark, A. [2 ]
机构：
[1] VU Med Ctr, Canc Ctr Amsterdam, Neurooncol Res Grp, Dept Neurosurg, Amsterdam, Netherlands
[2] Umea Univ, Dept Radiat Sci, Umea, Sweden
[3] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA
[4] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA
[5] Harvard Univ, Sch Med, Neurosci Program, Boston, MA 02115 USA
[6] Umea Univ, Dept Clin Immunol, Umea, Sweden
来源：
BRITISH JOURNAL OF CANCER | 2009年 / 100卷 / 10期
关键词：
prostate cancer; prostasomes; tumour exosomes; biomarkers; PROMOTE TUMOR-GROWTH; DIAGNOSTIC BIOMARKERS; FUSION; GENE; SEDIMENTS; ANTIGEN; TMPRSS2; PCA3;
D O I：
10.1038/sj.bjc.6605058
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2: ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status. British Journal of Cancer ( 2009) 100, 1603-1607. doi: 10.1038/sj.bjc.6605058 www.bjcancer.com Published online 28 April 2009 (C) 2009 Cancer Research UK
引用
收藏
页码：1603 / 1607
页数：5
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