Impaired nocturnal synthesis of melatonin in patients with cardiac syndrome X

被引:38
作者
Altun, A [1 ]
Yaprak, M
Aktoz, M
Vardar, A
Betul, U
Ozbay, G
机构
[1] Trakya Univ, Sch Med, Dept Cardiol, TR-22030 Edirne, Turkey
[2] Trakya Univ, Sch Med, Dept Physiol, TR-22030 Edirne, Turkey
[3] Trakya Univ, Sch Med, Dept Internal Med, TR-22030 Edirne, Turkey
关键词
nervous system; sympathovagal imbalance; angina; normal coronary angiography;
D O I
10.1016/S0304-3940(02)00368-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We investigated nocturnal secretion pattern of melatonin in patients with cardiac syndrome X and healthy subjects. The present study performed in five patients with cardiac syndrome X and in nine healthy controls. Blood samples from all subjects were collected every 2 h intervals between 22:00 and 08:00 h. Melatonin levels were measured with a radioimmunoassay kit. Patients with cardiac syndrome X secreted less nocturnal melatonin at 02:00 h than control subjects (P = 0.04). Peak and Delta melatonin (peak-lowest melatonin) were found lower in patients with cardiac syndrome X (P = 0.039 and P = 0.028, respectively). In conclusion patients with cardiac syndrome X show a markedly decreased nocturnal melatonin synthesis. Our study provides useful information about melatonin synthesis and release in patients with cardiac syndrome X might help physicians in managing these patients. (C) 2002 Published by Elsevier Science Ireland Ltd.
引用
收藏
页码:143 / 145
页数:3
相关论文
共 13 条
[1]   Impaired baroreflex sensitivity and sympathovagal balance in syndrome X [J].
Adamopoulos, S ;
Rosano, GMC ;
Ponikowski, P ;
Cerquetani, E ;
Piepoli, M ;
Panagiota, F ;
Collins, P ;
Poole-Wilson, P ;
Kremastinos, D ;
Coats, AJS .
AMERICAN JOURNAL OF CARDIOLOGY, 1998, 82 (07) :862-868
[2]  
ALTUN A, 2002, IN PRESS CAN J CARDI, V18
[3]  
ALTUN A, 1997, P EUROPACE 97 8 EUR, P155
[4]   Effects of melatonin an vascular reactivity, catecholamine levels, and blood pressure in healthy men [J].
Arangino, S ;
Cagnacci, A ;
Angiolucci, M ;
Vacca, AMB ;
Longu, G ;
Volpe, A ;
Melis, GB .
AMERICAN JOURNAL OF CARDIOLOGY, 1999, 83 (09) :1417-+
[5]   IMPAIRED NOCTURNAL SECRETION OF MELATONIN IN CORONARY HEART-DISEASE [J].
BRUGGER, P ;
MARKTL, W ;
HEROLD, M .
LANCET, 1995, 345 (8962) :1408-1408
[6]   Influences of melatonin administration on the circulation of women [J].
Cagnacci, A ;
Arangino, S ;
Angiolucci, M ;
Maschio, E ;
Melis, GB .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1998, 274 (02) :R335-R338
[7]   Low urinary 6-sulphatoxymelatonin levels in patients with coronary artery disease [J].
Girotti, L ;
Lago, M ;
Ianovsky, O ;
Carbajales, J ;
Elizari, MV ;
Brusco, LI ;
Cardinali, DP .
JOURNAL OF PINEAL RESEARCH, 2000, 29 (03) :138-142
[8]  
Lanza G A, 2000, Ital Heart J, V1, P221
[9]  
Nishiyama K, 2001, Am Heart J, V141, pE9, DOI 10.1067/mhj.2001.114368
[10]   Melatonin: A clinical perspective [J].
Penev, PD ;
Zee, PC .
ANNALS OF NEUROLOGY, 1997, 42 (04) :545-553