Long-Term Small Molecule and Protein Elution from TiO2 Nanotubes

被引：183

作者：

Peng, Lily ^{[1
,2
]}

Mendelsohn, Adam D. ^{[1
,2
]}

LaTempa, Thomas J. ^{[3
,4
]}

Yoriya, Sorachon ^{[3
,4
]}

Grimes, Craig A. ^{[3
,4
]}

Desai, Tejal A. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA

[3] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA

[4] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA

来源：

NANO LETTERS | 2009年 / 9卷 / 05期

基金：

美国国家科学基金会;

关键词：

TITANIA NANOTUBES; FABRICATION; TACROLIMUS; ARRAYS;

D O I：

10.1021/nl9001052

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, TiO2 nanotubes of various dimensions were used to elute albumin, a large protein molecule, as well as sirolimus and paclitaxel, common small molecule drugs. The nanotubes controlled small molecule diffusion for weeks and large molecule diffusion for a month. Drug eluted from the nanotubes was bioactive and decreased cell proliferation in vitro. Elution kinetics was most profoundly affected by tube height. This study demonstrates that TiO2 nanotubes may be a promising candidate for a drug-eluting implant coating.

引用

页码：1932 / 1936

页数：5

共 18 条

[1]

AINSLIE KM, 2008, J BIOMED MAT RES A, P35501

[2] Vascular pathology as a result of drug-eluting stents [J].

Bennett, Martin R. .

HEART, 2007, 93 (08) :895-896

[3] Enhanced cellular mobility guided by TiO2 nanotube surfaces [J].

Brammer, Karla S. ;

Oh, Seunghan ;

Gallagher, John O. ;

Jin, Sungho .

NANO LETTERS, 2008, 8 (03) :786-793

[4] The effect of electrolyte composition on the fabrication of self-organized titanium oxide nanotube arrays by anodic oxidation [J].

Cai, QY ;

Paulose, M ;

Varghese, OK ;

Grimes, CA .

JOURNAL OF MATERIALS RESEARCH, 2005, 20 (01) :230-236

[5] Capillary effects, wetting behavior and photo-induced tube filling of TiO2 nanotube layers [J].

Kim, Doohun ;

Macak, Jan M. ;

Schimidt-Stein, Felix ;

Schmuki, Patrik .

NANOTECHNOLOGY, 2008, 19 (30)

[6] Particle debris from a nanoporous stent coating obscures potential antiproliferative effects of tacrolimus-eluting stents in a porcine model of restenosis [J].

Kollum, M ;

Farb, A ;

Schreiber, R ;

Terfera, K ;

Arab, A ;

Geist, A ;

Haberstroh, J ;

Wnendt, S ;

Virmani, R ;

Hehrlein, C .

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2005, 64 (01) :85-90

[7] Sol-gel deposited TiO2 film on NiTi surgical alloy for biocompatibility improvement [J].

Liu, JX ;

Yang, DZ ;

Shi, F ;

Cai, YJ .

THIN SOLID FILMS, 2003, 429 (1-2) :225-230

[8] Fabrication of tapered, conical-shaped titania nanotubes [J].

Mor, GK ;

Varghese, OK ;

Paulose, M ;

Mukherjee, N ;

Grimes, CA .

JOURNAL OF MATERIALS RESEARCH, 2003, 18 (11) :2588-2593

[9] Nanosize and vitality:: TiO2 nanotube diameter directs cell fate [J].

Park, Jung ;

Bauer, Sebastian ;

von der Mark, Klaus ;

Schmuki, Patrik .

NANO LETTERS, 2007, 7 (06) :1686-1691

[10] The effect of TiO2 nanotubes on endothelial function and smooth muscle proliferation [J].

Peng, Lily ;

Eltgroth, Matthew L. ;

LaTempa, Thomas J. ;

Grimes, Craig A. ;

Desai, Tejal A. .

BIOMATERIALS, 2009, 30 (07) :1268-1272

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