Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus

被引：36

作者：

Zhang, Wangxin ^{[1
,2
]}

Zhang, Qiuling ^{[2
]}

Deng, Wen ^{[2
]}

Li, Yalu ^{[2
]}

Xing, Guoqing ^{[2
]}

Shi, Xianjun ^{[2
]}

Du, Yifeng ^{[1
]}

机构：

[1] Shandong Univ, Shandong Prov Hosp, Dept Neurol, Jinan 250021, Shandong, Peoples R China

[2] Taishan Med Univ, Dept Med Psychol, Tai An, Shandong, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 15期

关键词：

nerve regeneration; cerebral ischemia/reperfusion; ganoderma lucidum; anti-oxidative; anti-inflammatory; superoxide dismutase; malondialdehyde; interleukin-8; tumor necrosis factor-alpha; apoptosis; hippocampus; neural regeneration; ACUTE ISCHEMIC-STROKE; OXIDATIVE STRESS; ANTIOXIDANT ACTIVITIES; INFLAMMATORY RESPONSE; BRAIN-DAMAGE; POLYSACCHARIDES; MICE; MECHANISMS; IRRADIATION; PATHWAY;

D O I：

10.4103/1673-5374.139461

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ganoderma lucidum is a traditional Chinese medicine, which has been shown to have both anti-oxidative and anti-inflammatory effects, and noticeably decreases both the infarct area and neuronal apoptosis of the ischemic cortex. This study aimed to investigate the protective effects and mechanisms of pretreatment with ganoderma lucidum (by intragastric administration) in cerebral ischemia/reperfusion injury in rats. Our results showed that pretreatment with ganoderma lucidum for 3 and 7 days reduced neuronal loss in the hippocampus, diminished the content of malondialdehyde in the hippocampus and serum, decreased the levels of tumor necrosis factor-a and interleukin-8 in the hippocampus, and increased the activity of superoxide dismutase in the hippocampus and serum. These results suggest that pretreatment with ganoderma lucidum was protective against cerebral ischemia/reperfusion injury through its anti-oxidative and anti-inflammatory actions.

引用

页码：1446 / 1452

页数：7

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