Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus

被引:36
作者
Zhang, Wangxin [1 ,2 ]
Zhang, Qiuling [2 ]
Deng, Wen [2 ]
Li, Yalu [2 ]
Xing, Guoqing [2 ]
Shi, Xianjun [2 ]
Du, Yifeng [1 ]
机构
[1] Shandong Univ, Shandong Prov Hosp, Dept Neurol, Jinan 250021, Shandong, Peoples R China
[2] Taishan Med Univ, Dept Med Psychol, Tai An, Shandong, Peoples R China
关键词
nerve regeneration; cerebral ischemia/reperfusion; ganoderma lucidum; anti-oxidative; anti-inflammatory; superoxide dismutase; malondialdehyde; interleukin-8; tumor necrosis factor-alpha; apoptosis; hippocampus; neural regeneration; ACUTE ISCHEMIC-STROKE; OXIDATIVE STRESS; ANTIOXIDANT ACTIVITIES; INFLAMMATORY RESPONSE; BRAIN-DAMAGE; POLYSACCHARIDES; MICE; MECHANISMS; IRRADIATION; PATHWAY;
D O I
10.4103/1673-5374.139461
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Ganoderma lucidum is a traditional Chinese medicine, which has been shown to have both anti-oxidative and anti-inflammatory effects, and noticeably decreases both the infarct area and neuronal apoptosis of the ischemic cortex. This study aimed to investigate the protective effects and mechanisms of pretreatment with ganoderma lucidum (by intragastric administration) in cerebral ischemia/reperfusion injury in rats. Our results showed that pretreatment with ganoderma lucidum for 3 and 7 days reduced neuronal loss in the hippocampus, diminished the content of malondialdehyde in the hippocampus and serum, decreased the levels of tumor necrosis factor-a and interleukin-8 in the hippocampus, and increased the activity of superoxide dismutase in the hippocampus and serum. These results suggest that pretreatment with ganoderma lucidum was protective against cerebral ischemia/reperfusion injury through its anti-oxidative and anti-inflammatory actions.
引用
收藏
页码:1446 / 1452
页数:7
相关论文
共 42 条
[1]  
Atlas iMA, 2013, ARCH TRAUMA RES, V2, P124
[2]   The complexity of neurobiological processes in acute ischemic stroke [J].
Brouns, R. ;
De Deyn, P. P. .
CLINICAL NEUROLOGY AND NEUROSURGERY, 2009, 111 (06) :483-495
[3]  
Candelario-Jalil E, 2009, CURR OPIN INVEST DR, V10, P644
[4]   Role of oxidants in ischemic brain damage [J].
Chan, PH .
STROKE, 1996, 27 (06) :1124-1129
[5]  
Cieslak M, 2013, ACTA BIOCHIM POL, V60, P345
[6]   STUDIES ON LIPID-PEROXIDATION IN THE RAT-BRAIN [J].
CINI, M ;
FARIELLO, RG ;
BIANCHETTI, A ;
MORETTI, A .
NEUROCHEMICAL RESEARCH, 1994, 19 (03) :283-288
[7]   Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum [J].
Dudhgaonkar, Shailesh ;
Thyagarajan, Anita ;
Sliva, Daniel .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2009, 9 (11) :1272-1280
[8]   The hippocampus and declarative memory: cognitive mechanisms and neural codes [J].
Eichenbaum, H .
BEHAVIOURAL BRAIN RESEARCH, 2001, 127 (1-2) :199-207
[9]   Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat [J].
Gao, YH ;
Zhou, SF ;
Wen, JB ;
Huang, M ;
Xu, AL .
LIFE SCIENCES, 2002, 72 (06) :731-745
[10]   MODULATION OF LEUKOCYTE ADHESION MOLECULES, A T-CELL CHEMOTAXIN (IL-8) AND A REGULATORY CYTOKINE (TNF-ALPHA) IN ALLERGIC CONTACT-DERMATITIS (RHUS DERMATITIS) [J].
GRIFFITHS, CEM ;
BARKER, JNWN ;
KUNKEL, S ;
NICKOLOFF, BJ .
BRITISH JOURNAL OF DERMATOLOGY, 1991, 124 (06) :519-526