A stepwise approach to the management of metastatic midgut carcinoid tumor

被引：9

作者：

Bhattacharyya, Sanjeev ^{[2
]}

Gujral, Dorothy M. ^{[1
]}

Toumpanakis, Christos ^{[1
]}

Dreyfus, Gilles ^{[4
]}

Davidson, Brian R. ^{[3
]}

Davar, Joseph ^{[2
]}

Caplin, Martyn E. ^{[1
]}

机构：

[1] Royal Free Hosp, Neuroendocrine Tumour Unit, London NW3 2QG, England

[2] Royal Free Hosp, Dept Cardiol, London NW3 2QG, England

[3] Royal Free Hosp, HPB & Liver Transplant Surg, London NW3 2QG, England

[4] Royal Brompton & Harefield NHS Trust, Harefield Hosp, Dept Cardiothorac Surg, London, England

来源：

NATURE REVIEWS CLINICAL ONCOLOGY | 2009年 / 6卷 / 07期

关键词：

CONSENSUS GUIDELINES; LIVER; RESECTION;

D O I：

10.1038/nrclinonc.2009.70

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background. a 48-year-old man presented with diarrhea, flushing, abdominal pain and weight loss of 10 kg over a 6-month period. He subsequently developed dyspnea on exertion. Investigations. Physical examination, laboratory tests, CT of the abdomen, liver biopsy, echocardiography, immunohistochemistry staining of the biopsy specimen for neuroendocrine markers including chromogranin a, synaptophysin and protein gene product 9.5, and In-111-pentetreotide scintigraphy (Octreoscan (TM)). Diagnosis. carcinoid tumor of midgut origin with large segment 3 liver metastasis. carcinoid syndrome and carcinoid heart disease. Management. symptomatic relief with somatostatin analog therapy and subsequent resection of the segment 3 liver metastasis. tricuspid and pulmonary valve replacement.

引用

页码：429 / 433

页数：5

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