Successful aging: Advancing the science of physical independence in older adults

被引：167

作者：

Anton, Stephen D. ^{[1
]}

Woods, Adam J. ^{[1
,2
]}

Ashizawa, Tetso ^{[3
]}

Barb, Diana ^{[1
,4
]}

Buford, Thomas W. ^{[1
]}

Carter, Christy S. ^{[1
]}

Clark, David J. ^{[1
]}

Cohen, Ronald A. ^{[2
]}

Corbett, Duane B. ^{[1
]}

Cruz-Almeida, Yenisel ^{[1
,2
]}

Dotson, Vonetta ^{[2
]}

Ebner, Natalie ^{[5
]}

Efron, Philip A. ^{[6
]}

Fillingim, Roger B. ^{[7
]}

Foster, Thomas C. ^{[2
,8
]}

Gundermann, David M. ^{[1
]}

Joseph, Anna-Maria ^{[1
]}

Karabetian, Christy ^{[1
,9
]}

Leeuwenburgh, Christiaan ^{[1
]}

Manini, Todd M. ^{[1
]}

Marsiske, Michael ^{[9
]}

Mankowski, Robert T. ^{[1
]}

Mutchie, Heather L. ^{[1
]}

Perri, Michael G. ^{[9
]}

Ranka, Sanjay ^{[10
]}

Rashidi, Parisa ^{[11
]}

Sandesara, Bhanuprasad ^{[1
]}

Scarpace, Philip J. ^{[12
]}

Sibille, Kimberly T. ^{[1
]}

Solberg, Laurence M. ^{[1
]}

Someya, Shinichi ^{[1
]}

Uphold, Connie ^{[1
]}

Wohlgemuth, Stephanie ^{[13
]}

Wu, Samuel Shangwu ^{[14
]}

Pahor, Marco ^{[1
]}

机构：

[1] Univ Florida, Dept Aging & Geriatr Res, Gainesville, FL 32611 USA

[2] Univ Florida, Cognit Aging & Memory Clin Translat Res Program, Gainesville, FL 32611 USA

[3] Univ Florida, Dept Neurol, Gainesville, FL 32610 USA

[4] Univ Florida, Dept Med, Gainesville, FL 32610 USA

[5] Univ Florida, Dept Psychol, Gainesville, FL 32611 USA

[6] Univ Florida, Dept Surg, Gainesville, FL 32610 USA

[7] Univ Florida, Dept Community Dent & Behav Sci, Gainesville, FL 32610 USA

[8] Univ Florida, Dept Neurosci, Gainesville, FL 32610 USA

[9] Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL 32610 USA

[10] Univ Florida, Dept Comp & Informat Sci & Engn, Gainesville, FL 32611 USA

[11] Univ Florida, Dept Biomed Engn, Gainesville, FL 32610 USA

[12] Univ Florida, Dept Pharmacol & Therapeut, Gainesville, FL 32610 USA

[13] Univ Florida, Dept Anim Sci, Gainesville, FL 32611 USA

[14] Univ Florida, Dept Biostat, Gainesville, FL 32611 USA

来源：

AGEING RESEARCH REVIEWS | 2015年 / 24卷

关键词：

Age; Mobility; Obesity; Sarcopenia; Healthspan; Longevity; DIRECT-CURRENT STIMULATION; CONVERTING-ENZYME-INHIBITORS; LOWER-EXTREMITY FUNCTION; NONINVASIVE BRAIN-STIMULATION; TARGETED ANTIOXIDANTS PROTECT; WHITE-MATTER HYPERINTENSITIES; MITOCHONDRIAL-DNA MUTATIONS; PERIPHERAL-NERVE FUNCTION; LIFE-STYLE INTERVENTIONS; MUSCLE FAT INFILTRATION;

D O I：

10.1016/j.arr.2015.09.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The concept of 'successful aging' has long intrigued the scientific community. Despite this long-standing interest, a consensus definition has proven to be a difficult task, due to the inherent challenge involved in defining such a complex, multi-dimensional phenomenon. The lack of a clear set of defining characteristics for the construct of successful aging has made comparison of findings across studies difficult and has limited advances in aging research. A consensus on markers of successful aging is furthest developed is the domain of physical functioning. For example, walking speed appears to be an excellent surrogate marker of overall health and predicts the maintenance of physical independence, a cornerstone of successful aging. The purpose of the present article is to provide an overview and discussion of specific health conditions, behavioral factors, and biological mechanisms that mark declining mobility and physical function and promising interventions to counter these effects. With life expectancy continuing to increase in the United States and developed countries throughout the world, there is an increasing public health focus on the maintenance of physical independence among all older adults. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：304 / 327

页数：24

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