Cancer's molecular sweet tooth and the Warburg effect

被引：970

作者：

Kim, Jung-whan

Dang, Chi V.

机构：

[1] Johns Hopkins Univ, Sch Med, Div Hematol, Dept Med, Baltimore, MD USA

[2] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr John Hopkins, Baltimore, MD USA

来源：

CANCER RESEARCH | 2006年 / 66卷 / 18期

关键词：

D O I：

10.1158/0008-5472.CAN-06-1501

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

More than 80 years ago, the renowned biochemist Otto Warburg described how cancer cells avidly consume glucose and produce lactic acid under aerobic conditions. Recent studies arguing that cancer cells benefit from this phenomenon, termed the Warburg effect, have renewed discussions about its exact role as cause, correlate, or facilitator of cancer. Molecular advances in this area may reveal tactics to exploit the cancer cell's "sweet tooth" for cancer therapy.

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页码：8927 / 8930

页数：4

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