Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men

被引：474

作者：

Freedman, Matthew L.

Haiman, Christopher A.

Patterson, Nick

McDonald, Gavin J.

Tandon, Arti

Waliszewska, Alicja

Penney, Kathryn

Steen, Robert G.

Ardlie, Kristin

John, Esther M.

Clakley-Girvan, Ingrid

Whitternore, Alice S.

Cooney, Kathleen A.

Ingles, Sue A.

Altshuler, David

Henderson, Brian E.

Reich, David

机构：

[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Biopolymers Facil, Boston, MA 02115 USA

[4] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[5] MIT, Cambridge, MA 02142 USA

[6] Broad Inst Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA

[7] Univ So Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90089 USA

[8] Brigham & Womens Hosp, Ctr Neurol Dis, Lab Mol Immunol, Boston, MA 02115 USA

[9] SeraCare Life Sci Inc, Genom Collaborat, Cambridge, MA 02139 USA

[10] No Calif Canc Ctr, Fremont, CA 94538 USA

[11] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA

[12] Univ Michigan, Dept Med, Ann Arbor, MI 48109 USA

[13] Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA

[14] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[15] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA

[16] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 38期

关键词：

association; human genetics;

D O I：

10.1073/pnas.0605832103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on chromosome 8q24 as significantly associated with susceptibility to prostate cancer [logarithm of odds (LOD) = 7.1]. The increased risk because of inheriting African ancestry is greater in men diagnosed before 72 years of age (P < 0.00032) and may contribute to the epidemiological observation that the higher risk for prostate cancer in African Americans is greatest in younger men (and attenuates with older age). The same region was recently identified through linkage analysis of prostate cancer, followed by fine-mapping. We strongly replicated this association (P < 4.2 x 10(-9)) but find that the previously described alleles do not explain more than a fraction of the admixture signal. Thus, admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it.

引用

页码：14068 / 14073

页数：6

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