Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones

被引：8

作者：

Il'ina, I. V. ^{[1
,2
]}

Korchagina, D. V. ^{[1
]}

Morozova, E. A. ^{[1
]}

Tolstikova, T. G. ^{[1
]}

Volcho, K. P. ^{[1
,2
]}

Salakhutdinov, N. F. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Prosp Akad Lavrentieva, Novosibirsk 630090, Russia

[2] Novosibirsk Natl Res State Univ, 1 Ul Pirogova, Novosibirsk 630090, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2019年 / 68卷 / 05期

关键词：

monoterpenoids; montmorillonite K10; heterocyclic compounds; analgesic activity; ISOPULEGOL; VANILLIN; ACIDITY;

D O I：

10.1007/s11172-019-2520-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of compounds with a hydrogenated 2H-chromene skeleton was synthesized by the reaction of ketones and available para-menthane monoterpenoid ()-isopulegol. A condensation product of ()-isopulegol with the monoterpene ketone l-menthone was synthesized for the first time. The synthesized heterocycles were tested for analgesic activity and compounds with high analgesic activity in the in vivo tests were identified.

引用

页码：1061 / 1066

页数：6

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