An efficient one-pot synthesis of octahydroquinazolinone derivatives using catalytic amount of H2SO4 in water

被引：104

作者：

Hassani, Zahra ^{[1
]}

Islami, Mohammad Reza ^{[1
]}

Kalantari, Maryam ^{[1
]}

机构：

[1] Shahid Bahonar Univ Kerman, Dept Chem, Kerman 76169, Iran

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 17期

关键词：

octahydroquinazolinones; dimedone; Biginelli reaction;

D O I：

10.1016/j.bmcl.2006.06.038

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this investigation, a practical green chemistry procedure for synthesis of octahydroquinazolinone according to the Biginelli reaction using 5,5-dimethyl-1,3-cyclohexanedione, urea or thiourea, and appropriate aromatic aldehydes in the presence of two drops of concentrated H2SO4 as a catalyst is described in water. This methodology is of interest due to the use of water as a solvent without use of any organic solvent and toxic metals as catalyst, thus minimizing the cost, the operational hazards, and environmental pollution. Also this modified route provides much higher yields and simple work-up procedure of products. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4479 / 4482

页数：4

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