Metabolic Asymmetry in Cancer: A "Balancing Act" that Promotes Tumor Growth

被引:19
作者
Martinez-Outschoorn, Ubaldo E. [1 ]
Sotgia, Federica [2 ,3 ]
Lisanti, Michael P. [2 ,3 ]
机构
[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
[2] Univ Manchester, Inst Canc Sci, Breakthrough Breast Canc Res Unit, Manchester M13 9PL, Lancs, England
[3] Univ Manchester, Inst Canc Sci, MCCM, Manchester M13 9PL, Lancs, England
关键词
FIBROBLASTS; AUTOPHAGY; CELLS; MICE; P62;
D O I
10.1016/j.ccr.2014.06.021
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:5 / 7
页数:3
相关论文
共 10 条
[1]  
Bernard D, 2003, J CLIN INVEST, V112, P1724
[2]   Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production [J].
Capparelli, Claudia ;
Guido, Carmela ;
Whitaker-Menezes, Diana ;
Bonuccelli, Gloria ;
Balliet, Renee ;
Pestell, Timothy G. ;
Goldberg, Allison F. ;
Pestell, Richard G. ;
Howell, Anthony ;
Sneddon, Sharon ;
Birbe, Ruth ;
Tsirigos, Aristotelis ;
Martinez-Outschoorn, Ubaldo ;
Sotgia, Federica ;
Lisanti, Michael P. .
CELL CYCLE, 2012, 11 (12) :2285-2302
[3]   HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells Autophagy drives compartment-specific oncogenesis [J].
Chiavarina, Barbara ;
Whitaker-Menezes, Diana ;
Migneco, Gemma ;
Martinez-Outschoorn, Ubaldo E. ;
Pavlides, Stephanos ;
Howell, Anthony ;
Tanowitz, Herbert B. ;
Casimiro, Mathew C. ;
Wang, Chenguang ;
Pestell, Richard G. ;
Grieshaber, Philip ;
Caro, Jaime ;
Sotgia, Federica ;
Lisanti, Michael P. .
CELL CYCLE, 2010, 9 (17) :3534-3551
[4]   Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia [J].
Das, Suman K. ;
Eder, Sandra ;
Schauer, Silvia ;
Diwoky, Clemens ;
Temmel, Hannes ;
Guertl, Barbara ;
Gorkiewicz, Gregor ;
Tamilarasan, Kuppusamy P. ;
Kumari, Pooja ;
Trauner, Michael ;
Zimmermann, Robert ;
Vesely, Paul ;
Haemmerle, Guenter ;
Zechner, Rudolf ;
Hoefler, Gerald .
SCIENCE, 2011, 333 (6039) :233-238
[5]   p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway [J].
Duran, Angeles ;
Amanchy, Ramars ;
Linares, Juan F. ;
Joshi, Jayashree ;
Abu-Baker, Shadi ;
Porollo, Aleksey ;
Hansen, Malene ;
Moscat, Jorge ;
Diaz-Meco, Maria T. .
MOLECULAR CELL, 2011, 44 (01) :134-146
[6]   Critical transitions in a game theoretic model of tumour metabolism [J].
Kianercy, Ardeshir ;
Veltri, Robert ;
Pienta, Kenneth J. .
INTERFACE FOCUS, 2014, 4 (04)
[7]   Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice [J].
Komatsu, Masaaki ;
Waguri, Satoshi ;
Koike, Masato ;
Sou, Yu-shin ;
Ueno, Takashi ;
Hara, Taichi ;
Mizushima, Noboru ;
Iwata, Jun-ichi ;
Ezaki, Junji ;
Murata, Shigeo ;
Hamazaki, Jun ;
Nishito, Yasumasa ;
Iemura, Shun-ichiro ;
Natsume, Tohru ;
Yanagawa, Toru ;
Uwayama, Junya ;
Warabi, Eiji ;
Yoshida, Hiroshi ;
Ishii, Tetsuro ;
Kobayashi, Akira ;
Yamamoto, Masayuki ;
Yue, Zhenyu ;
Uchiyama, Yasuo ;
Kominami, Eiki ;
Tanaka, Keiji .
CELL, 2007, 131 (06) :1149-1163
[8]   Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth [J].
Martinez-Outschoorn, Ubaldo E. ;
Lisanti, Michael P. ;
Sotgia, Federica .
SEMINARS IN CANCER BIOLOGY, 2014, 25 :47-60
[9]   Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice [J].
Sonveaux, Pierre ;
Vegran, Frederique ;
Schroeder, Thies ;
Wergin, Melanie C. ;
Verrax, Julien ;
Rabbani, Zahid N. ;
De Saedeleer, Christophe J. ;
Kennedy, Kelly M. ;
Diepart, Caroline ;
Jordan, Benedicte F. ;
Kelley, Michael J. ;
Gallez, Bernard ;
Wahl, Miriam L. ;
Feron, Olivier ;
Dewhirst, Mark W. .
JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (12) :3930-3942
[10]   Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis [J].
Valencia, Tania ;
Kim, Ji Young ;
Abu-Baker, Shadi ;
Moscat-Pardos, Jorge ;
Ahn, Christopher S. ;
Reina-Campos, Miguel ;
Duran, Angeles ;
Castilla, Elias A. ;
Metallo, Christian M. ;
Diaz-Meco, Maria T. ;
Moscat, Jorge .
CANCER CELL, 2014, 26 (01) :121-135