Long non-coding RNA (lncRNA). Gene and genome regulation

被引：1

作者：

Maass, P. G. ^{[1
]}

机构：

[1] Max Delbruck Ctr Mol Med MDC, D-13125 Berlin, Germany

来源：

MEDIZINISCHE GENETIK | 2014年 / 26卷 / 01期

关键词：

Gene expression regulation; Histone code; Long noncoding RNA; Genome; Chromosomal territories;

D O I：

10.1007/s11825-013-0432-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Long non-coding RNAs (lncRNAs) expand our knowledge of transcriptional or post-transcriptional gene regulation. In interaction with the nuclear architecture, lncRNAs are involved in fundamental biological mechanisms, such as imprinting, histone code regulation, gene activation, gene repression, lineage determinations, and cell proliferation. Associations with apparent phenotypes have been attributed to lncRNAs. The involvement of lncRNA in gene regulation and disease underscores the importance of lncRNA-mediated regulatory networks. Manipulating lncRNAs is a conceivable therapeutic strategy because of their tissue-specific expression and their selective target genes.

引用

页码：5 / 10

页数：6

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