Long non-coding RNA (lncRNA). Gene and genome regulation

Long non-coding RNAs (lncRNAs) expand our knowledge of transcriptional or post-transcriptional gene regulation. In interaction with the nuclear architecture, lncRNAs are involved in fundamental biological mechanisms, such as imprinting, histone code regulation, gene activation, gene repression, lineage determinations, and cell proliferation. Associations with apparent phenotypes have been attributed to lncRNAs. The involvement of lncRNA in gene regulation and disease underscores the importance of lncRNA-mediated regulatory networks. Manipulating lncRNAs is a conceivable therapeutic strategy because of their tissue-specific expression and their selective target genes.