Medial prefrontal D1 dopamine neurons control food intake

被引：132

作者：

Land, Benjamin B. ^{[1
,2
]}

Narayanan, Nandakumar S. ^{[1
,2
,3
]}

Liu, Rong-Jian ^{[1
,2
]}

Gianessi, Carol A. ^{[1
,2
]}

Brayton, Catherine E. ^{[1
,2
]}

Grimaldi, David M. ^{[1
,2
]}

Sarhan, Maysa ^{[1
,2
]}

Guarnieri, Douglas J. ^{[1
,2
]}

Deisseroth, Karl ^{[4
,5
]}

Aghajanian, George K. ^{[1
,2
]}

DiLeone, Ralph J. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Ribicoff Res Facil, New Haven, CT USA

[3] Univ Iowa, Dept Neurol, Carver Coll Med, Iowa City, IA 52242 USA

[4] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[5] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA

来源：

NATURE NEUROSCIENCE | 2014年 / 17卷 / 02期

关键词：

LATERAL HYPOTHALAMUS; RECEPTOR STIMULATION; FRONTAL-CORTEX; DEFICIENT MICE; REWARD; ACCUMBENS; RATS; TRANSMISSION; MODULATION; ACTIVATION;

D O I：

10.1038/nn.3625

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. Food intake increases activity in D1 neurons of the mPFC in mice, and optogenetic photostimulation of D1 neurons increases feeding. Conversely, inhibition of D1 neurons decreases intake. Stimulation-based mapping of prefrontal D1 neuron projections implicates the medial basolateral amygdala (mBLA) as a downstream target of these afferents. mBLA neurons activated by prefrontal D1 stimulation are CaMKII positive and closely juxtaposed to prefrontal D1 axon terminals. Finally, photostimulating these axons in the mBLA is sufficient to increase feeding, recapitulating the effects of mPFC D1 stimulation. These data describe a new circuit for top-down control of food intake.

引用

页码：248 / 253

页数：6

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