Cell death paradigms in the pathogenesis of Mycobacterium tuberculosis infection

被引:35
|
作者
Parandhaman, Dinesh Kumar [1 ,2 ]
Narayanan, Sujatha [1 ]
机构
[1] Natl Inst Res TB, Dept Immunol, Madras, Tamil Nadu, India
[2] Int Ctr Genet Engn & Biotechnol, Dept Immunol, New Delhi, India
来源
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2014年 / 4卷
关键词
apoptosis; pyroptosis; intrinsic pathway; extrinsic pathway; autophagy; Mycobacterium tuberculosis; INDUCED MACROPHAGE APOPTOSIS; INNATE IMMUNITY; PROTEIN; KINASE; NECROSIS; SURVIVAL; PATHWAY; ACTIVATION; INDUCTION; MECHANISMS;
D O I
10.3389/fcimb.2014.00031
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Cell death or senescence is a fundamental event that helps maintain cellular homeostasis, shapes the growth of organism, and provides protective immunity against invading pathogens. Decreased or increased cell death is detrimental both in infectious and non-infectious diseases. Cell death is executed both by regulated enzymic reactions and non-enzymic sudden collapse. In this brief review we have tried to summarize various cell death modalities and their impact on the pathogenesis of Mycobacterium tuberculosis.
引用
收藏
页数:7
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