Caloric restriction and cancer: molecular mechanisms and clinical implications

被引：99

作者：

Meynet, Ophelie ^{[1
,2
]}

Ricci, Jean-Ehrland ^{[1
,2
,3
]}

机构：

[1] INSERM, U1065, Ctr Mediterraneen Med Mol C3M, Equipe Controle Metab Morts Cellulaires, F-06204 Nice 3, France

[2] Univ Nice Sophia Antipolis, Fac Med, F-06100 Nice, France

[3] CHU Nice, Dept Anesthesie Reanimat, F-06204 Nice 3, France

来源：

TRENDS IN MOLECULAR MEDICINE | 2014年 / 20卷 / 08期

关键词：

caloric restriction; cancer; chemotherapy; mTOR; AMPK; immune response; INDUCED CARDIOMYOCYTE DEATH; CELL LUNG-CANCER; BODY-MASS INDEX; LIFE-SPAN; DIETARY RESTRICTION; TRANSCRIPTION FACTOR; METFORMIN DECREASES; RAPAMYCIN TREATMENT; INSULIN-RESISTANCE; TUMOR-SUPPRESSOR;

D O I：

10.1016/j.molmed.2014.05.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caloric restriction (CR) is currently the most robust environmental intervention known to increase healthy life and prolong lifespan in several models, from yeast to mice. Although the protective effect of CR on the incidence of cancer is well established, its impact on tumor cell responses to chemotherapeutic treatment is currently being investigated. Interestingly, the molecular mechanisms required to extend lifespan upon reduced food intake are being evaluated, and these mechanisms may offer new opportunities for therapeutic intervention. In addition, new findings suggest a beneficial effect of CR in enhancing the efficiency of tumor cell killing by chemotherapeutic drugs and inducing an anticancer immune response.

引用

页码：419 / 427

页数：9

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