Garcixanthones B and C, new xanthones from the pericarps of Garcinia mangostana and their cytotoxic activity

被引：34
作者：
Ibrahim, Sabrin R. M. [1 ,2 ]
Abdallah, Hossam M. [3 ,4 ]
El-Halawany, Ali M. [4 ]
Radwan, Mohammed F. [5 ,6 ]
Shehata, Ibrahim A. [3 ,4 ]
Al-Harshany, Essam M. [3 ]
Zayed, Mohamed F. [1 ]
Mohamed, Gamal A. [3 ,7 ]
机构：
[1] Taibah Univ, Dept Pharmacognosy & Pharmaceut Chem, Coll Pharm, Al Madinah Al Munawwarah 30078, Saudi Arabia
[2] Assiut Univ, Dept Pharmacognosy, Fac Pharm, Assiut 71526, Egypt
[3] King Abdulaziz Univ, Dept Nat Prod & Alternat Med, Fac Pharm, Jeddah 21589, Saudi Arabia
[4] Cairo Univ, Dept Pharmacognosy, Fac Pharm, Cairo 11562, Egypt
[5] King Abdulaziz Univ, Dept Pharmaceut Chem, Fac Pharm, Jeddah 21589, Saudi Arabia
[6] Menia Univ, Dept Med Chem, Fac Pharm, Al Minya 61519, Egypt
[7] Al Azhar Univ, Assiut Branch, Dept Pharmacognosy, Fac Pharm, Assiut 71524, Egypt
来源：
PHYTOCHEMISTRY LETTERS | 2018年 / 25卷
关键词：
Clusiaceae; Garcinia mangostana; Garcixanthones; Xanthones; Cytotoxic activity; FUNGUS FUSARIUM SP; TETRACYCLIC TRITERPENOIDS; FRUIT HULLS;
D O I：
10.1016/j.phytol.2018.03.009
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new prenylated xanthones, garcixanthones B (1) and C (2) and six known metabolites: gartanin (3), 1,3,8- trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl)-xanthone (4), rubraxanthone (5), 1,3,6,7-tetrahydroxy-8-prenylxanthone (6), garcinone C (7), and xanthone I (9-hydroxycalabaxanthone) (8) were separated from the EtOAc-soluble fraction of the air-dried pericarps of Garcinia mangostana (Clusiaceae). Their structures were verified on the basis of spectroscopic data analysis as well as by comparison with the literature. The cytotoxic activity of the new compounds was assessed against MCF7, A549, and HCT116 cell lines using sulforhodamine B (SRB) assay. Compounds 1 and 2 showed significant cytotoxic potential against MCF7 (human breast adenocarcinoma) and A549 (lung carcinoma) cell lines with IC(50)s 4.27 and 2.65 and 3.08 and 3.91 mu M, respectively compared to doxorubicin (0.06 and 0.44 mu M, respectively). However, they exhibited moderate activity towards HCT116 (colon carcinoma) cell line.
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页码：12 / 16
页数：5
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